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Temporal Trends and Outcomes of Left Ventricular Aneurysm After Acute Myocardial Infarction

Saraschandra Vallabhajosyula1, Siddak Kanwar2, Htin Aung3

  • 1Department of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic, Rochester, Minnesota; Center for Clinical and Translational Science, Mayo Clinic Graduate School of Biomedical Sciences, Rochester, Minnesota; Section of Interventional Cardiology, Division of Cardiovascular Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia.

The American Journal of Cardiology
|August 19, 2020
PubMed

Insights

Left ventricular aneurysms following acute myocardial infarction (AMI) are associated with increased complications and resource use, but not in-hospital mortality. This study highlights higher morbidity in patients with LV aneurysms post-AMI.

Area of Science:

  • Cardiology
  • Cardiovascular Research
  • Medical Data Analysis

Background:

  • Limited data exist on the prevalence and outcomes of left ventricular (LV) aneurysms after acute myocardial infarction (AMI).
  • Understanding these outcomes is crucial for managing post-MI cardiac complications.

Purpose of the Study:

  • To evaluate the prevalence, temporal trends, and in-hospital outcomes of LV aneurysms in patients with AMI.
  • To identify associated complications, hospitalization costs, and length of stay.

Main Methods:

  • Retrospective cohort study using the National Inpatient Sample (2000-2017).
  • Analysis of 11,622,528 AMI admissions, identifying 17,626 (0.2%) with LV aneurysms.
  • Comparison of demographic, comorbidity, complication, and outcome data between cohorts.

Main Results:

  • LV aneurysm prevalence slightly increased from 2000 to 2017, particularly with ST-segment-elevation AMI.
  • The LV aneurysm cohort experienced significantly higher rates of ventricular arrhythmias, mechanical complications, cardiac arrest, pump failure, and cardiogenic shock.
  • Despite increased morbidity, in-hospital mortality was comparable (7.4% vs 6.2%), but LV aneurysm patients had longer hospital stays, higher costs, and fewer home discharges.

Conclusions:

  • Left ventricular aneurysms following AMI are associated with significantly higher morbidity and increased healthcare resource utilization.
  • While complications are more frequent, LV aneurysms do not appear to increase in-hospital mortality compared to other AMI cases.
  • These findings underscore the importance of monitoring and managing LV aneurysms to mitigate associated complications and resource demands.

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