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Related Concept Videos

Imbalances in Cardiac Output01:26

Imbalances in Cardiac Output

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The heart's primary function is to pump blood throughout the body, maintaining a balance between blood sent out (cardiac output) and blood returning (venous return). If this balance is disrupted, it can result in congestive heart failure (CHF), a severe condition where the heart becomes an inefficient pump, leading to inadequate blood circulation.
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Rheumatic Heart Disease I: Introduction01:23

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Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
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Heart Failure I: Introduction01:27

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Heart failure refers to a clinical syndrome caused by structural or functional cardiac disorders that prevent the heart from pumping an adequate amount of blood to meet the body's metabolic needs. This condition often arises from myocardial infarction or ischemia, leading to decreased cardiac output, reduced tissue perfusion, impaired gas exchange, fluid volume imbalance, and decreased functional ability.Heart failure can result from disruptions in the mechanisms that regulate cardiac output...
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Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

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Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
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Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

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Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
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Acute Coronary Syndrome I: Introduction01:30

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Acute Coronary Syndrome (ACS) encompasses a spectrum of heart conditions caused by sudden obstruction of coronary arteries, typically resulting from the rupture of an atherosclerotic plaque and subsequent thrombus (blood clot) formation. This obstruction can lead to partial or complete blockage of blood flow, causing varying degrees of myocardial ischemia or infarction.ACS includes the following clinical entities:Unstable Angina (UA)Non-ST-Elevation Myocardial Infarction (NSTEMI)ST-Elevation...
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Tachycardia-Induced Cardiomyopathy As a Chronic Heart Failure Model in Swine
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Heart Dysfunction in Sepsis.

Ricardo Poveda-Jaramillo1

  • 1Clínica del Norte, Clínica Las Vegas, Anestesiar, Universidad CES, Envigado, Colombia.

Journal of Cardiothoracic and Vascular Anesthesia
|August 19, 2020
PubMed
Summary
This summary is machine-generated.

Sepsis frequently causes cardiac dysfunction due to molecular changes affecting the heart muscle. Understanding these alterations improves diagnostics and therapeutics for better patient outcomes.

Keywords:
Cardiac FunctionMyocardial DysfunctionSepsis

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Area of Science:

  • Cardiology
  • Molecular Biology
  • Pathophysiology

Background:

  • Cardiac involvement is a common complication during sepsis.
  • Molecular alterations at the cellular level lead to myocardial malfunction.
  • The heart's function is critical for supplying organs and tissues.

Purpose of the Study:

  • To summarize the molecular mechanisms of cardiac dysfunction in sepsis.
  • To highlight advancements in diagnostic strategies.
  • To discuss progress in therapeutic interventions for sepsis-induced cardiomyopathy.

Main Methods:

  • Review of current literature on sepsis and cardiac involvement.
  • Analysis of molecular pathways implicated in myocardial dysfunction.
  • Synthesis of data on diagnostic and therapeutic advancements.

Main Results:

  • Sepsis triggers specific molecular changes impacting cardiac cells.
  • Improved understanding has led to more precise diagnostic tools.
  • Therapeutic strategies have advanced, addressing molecular targets.

Conclusions:

  • Molecular insights are crucial for understanding sepsis-related heart problems.
  • Enhanced diagnostics and therapeutics are improving patient care.
  • Further research into molecular mechanisms can optimize treatment.