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Hyperbaric Oxygen Therapy Following Percutaneous Coronary Intervention for ST-Segment Elevation Myocardial Infarction

Patricia Martín-Hernández1, Hugo Gutiérrez-Leonard1, Asanté Reymon Quintana2

  • 1Cardiología Intervencionista del Hospital Central Militar, Mexico.

Cardiovascular Revascularization Medicine : Including Molecular Interventions
|August 19, 2020
PubMed

Insights

Hyperbaric oxygen therapy (HBOT) improved heart function in ST-elevation myocardial infarction (STEMI) patients after primary percutaneous coronary intervention (PPCI). This pilot study showed enhanced perfusion and ejection fraction with HBOT, suggesting its potential as a valuable treatment.

Area of Science:

  • Cardiology
  • Hyperbaric Medicine
  • Medical Imaging

Background:

  • Ischemic heart disease, including myocardial infarction (MI), often has poor outcomes despite timely revascularization.
  • Hyperbaric oxygen therapy (HBOT) is an emerging treatment for ischemic conditions.
  • Primary percutaneous coronary intervention (PPCI) is a standard treatment for ST-elevation myocardial infarction (STEMI).

Purpose of the Study:

  • To evaluate the effect of HBOT on single-photon emission computed tomography (SPECT) findings in STEMI patients treated with PPCI.
  • To compare SPECT findings at 6 weeks in STEMI patients receiving HBOT versus standard care.

Main Methods:

  • A pilot study randomized 24 STEMI patients undergoing PPCI into two groups: HBOT (n=13) and control (n=11).
  • The HBOT group received additional 15 and 90-minute HBOT sessions.
  • SPECT imaging was performed at baseline (within 48 hours of PPCI) and at 6-week follow-up for both groups.

Main Results:

  • The HBOT group showed a significant reduction in affected SPECT segments from baseline to 6 weeks (47.1% to 33.7%, p=0.039).
  • Both groups showed a decrease in summed rest score, with a significant reduction in the HBOT group (20 to 12.7, p=0.0017).
  • Left ventricular ejection fraction improved significantly in the HBOT group (44% to 57.2%, p=0.011) and the control group (45.9% to 55%, p=0.044).

Conclusions:

  • HBOT in STEMI patients undergoing PPCI was associated with improved myocardial perfusion and increased left ventricular ejection fraction.
  • These preliminary findings suggest HBOT may be a beneficial adjunctive therapy for STEMI.
  • A larger randomized clinical trial is warranted to confirm these results.
Abstract

Keywords:
Hyperbaric oxygen therapyMyocardial infarctionPercutaneous coronary intervention

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