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Related Experiment Videos

The glomerular tip lesion: a distinct entity or not?

W Huppes1, R J Hené, C J Kooiker

  • 1Department of Nephrology and Hypertension, University Hospital, Utrecht, The Netherlands.

The Journal of Pathology
|February 1, 1988
PubMed
Summary
This summary is machine-generated.

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The glomerular tip lesion (GTL) is not a distinct kidney disease. Studies show GTL does not differ from focal segmental glomerulosclerosis (FSGS) in clinical course or treatment response.

Area of Science:

  • Nephrology
  • Renal Pathology

Background:

  • A novel glomerulopathy, the glomerular tip lesion (GTL), was recently described.
  • GTL is characterized by intracapillary foam cells and epithelial cell vacuolization near the proximal tubule origin.
  • It was suggested to be distinct from focal segmental glomerulosclerosis (FSGS) with a potentially better steroid response.

Observation:

  • Five patients meeting GTL criteria were treated with corticosteroids or cyclosporin-A.
  • Proteinuria did not decrease significantly in treated patients.
  • Two patients experienced renal function decline, and one showed recurrent FSGS post-transplant.

Findings:

  • Glomerular tip lesion (GTL) did not respond to immunosuppressive therapy.
  • Treatment outcomes were similar to those seen in focal segmental glomerulosclerosis (FSGS).

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Implications:

  • Glomerular tip lesion (GTL) is likely not a distinct clinicopathological entity.
  • GTL should be considered within the spectrum of focal segmental glomerulosclerosis (FSGS).
  • Current treatment strategies for FSGS may be applicable to GTL.