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Updated: Dec 11, 2025

A Mouse Model of Incompletely Resected Soft Tissue Sarcoma for Testing Neoadjuvant Therapies

A Mouse Model of Incompletely Resected Soft Tissue Sarcoma for Testing Neoadjuvant Therapies

Published on: July 28, 2020

Pre- or postoperative radiotherapy for soft tissue sarcomas.

C Llacer-Moscardo¹, M Terlizzi², S Bonvalot³

¹Radiation Oncology Department, institut du cancer de Montpellier (ICM), 208, avenue des Apothicaires, parc Euromédecine, 34298 Montpellier cedex 5, France.

Cancer Radiotherapie : Journal De La Societe Francaise De Radiotherapie Oncologique

|August 19, 2020

Summary

Pre-operative radiotherapy for soft-tissue sarcomas may increase wound complications, while post-operative radiotherapy impacts long-term function. Both offer similar survival rates, guiding treatment decisions.

Keywords:

Biopsie Biopsy Chirurgie Imagerie Imaging Postoperative Postopératoire Preoperative Préopératoire Radiotherapy Radiothérapie Sarcomes des tissus mous Soft-tissue sarcomas Surgery

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Establishment of a Primary Culture of Patient-derived Soft Tissue Sarcoma

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Published on: April 11, 2018

Area of Science:

Oncology
Surgical Oncology
Radiation Oncology

Background:

Soft-tissue sarcomas are rare mesenchymal tumors requiring multimodal treatment.
Limb-sparing strategies combining surgery and radiotherapy are standard for localized extremity sarcomas.

Purpose of the Study:

To compare the advantages and disadvantages of pre-operative versus post-operative radiotherapy for soft-tissue sarcomas.
To inform clinical decision-making regarding the optimal timing of radiotherapy delivery.

Main Methods:

Review of current practices and evidence regarding pre- and post-operative radiotherapy for soft-tissue sarcomas.
Analysis of toxicity profiles and impact on local control and survival rates.

Main Results:

Both pre-operative and post-operative radiotherapy yield similar local control and survival rates.
Pre-operative radiotherapy is associated with increased wound complication risks.
Post-operative radiotherapy can negatively affect long-term functional outcomes.

Conclusions:

Technical advancements and improved wound management favor pre-operative radiotherapy.
Hypofractionation and nanoparticle potentiation further support pre-operative radiotherapy delivery.
The choice between pre- and post-operative radiotherapy depends on balancing oncologic outcomes with toxicity profiles.