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Updated: Dec 11, 2025
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In Silico Clinical Trials for Cardiovascular Disease
Published on: May 27, 2022
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Cardiac computational modelling
Jean R Bragard1, Oscar Camara2, Blas Echebarria3
1Grupo de Biofísica (BIOFIS), Departamento de Física y Matemática Aplicada, Universidad de Navarra, Pamplona, Navarra, Spain.
Revista Espanola De Cardiologia (English Ed.)
|August 19, 2020
Summary
Personalized computational models of the heart aid in understanding cardiovascular diseases and optimizing patient treatment. The VHeart-SN network aims to create an integrated, multiscale cardiac model for improved cardiac care.
Area of Science:
- Cardiovascular Research
- Computational Biology
- Medical Modeling
Background:
- Cardiovascular diseases (CVDs) pose significant social and economic burdens, being leading causes of death and illness.
- Personalized computational heart models offer valuable insights into cardiac disease mechanisms and treatment optimization.
- The Spanish Research Network for Cardiac Computational Modelling (VHeart-SN) has been established to advance this field.
Purpose of the Study:
- To develop an integrated, modular, multiscale, and multiphysical computational model of the heart.
- To advance understanding of cardiac and vascular disease mechanisms.
- To support the application of personalized therapies for cardiovascular conditions.
Main Methods:
- Integration of diverse numerical methods and patient-specific models.
- Multiscale and multiphysical modeling approaches.
- Collaborative research within the VHeart-SN network.
Main Results:
- The article outlines the current state of cardiac computational modeling.
- It details scientific contributions from VHeart-SN members.
- It highlights the utility and characteristics of these advanced models.
Conclusions:
- Cardiac computational modeling is crucial for understanding and treating cardiovascular diseases.
- The VHeart-SN network is developing a comprehensive cardiac model.
- These models promise to enhance personalized medicine and patient outcomes in cardiology.
