Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Multiple Allele Traits01:49

Multiple Allele Traits

37.6K
The Concept of Multiple Allelism
37.6K
Hemoglobin01:24

Hemoglobin

6.9K
Hemoglobin is a globular protein made up of four subunits. Two of these subunits are alpha chains, and the other two are beta chains. Each subunit contains a molecule of heme, which has an iron atom and can bind to oxygen. When an oxygen molecule binds to one heme group, it changes the shape of hemoglobin, making it easier for the other heme groups to bind oxygen as well.
When all four heme groups are bound to oxygen, the resulting molecule is called oxyhemoglobin. As a result, arterial blood...
6.9K
Oxygen Transport in the Blood01:27

Oxygen Transport in the Blood

5.3K
Hemoglobin (Hb) is a crucial molecule in the human body, consisting of four polypeptide chains, each bound to an iron-containing heme group. This unique structure enables hemoglobin to bind to oxygen, with each molecule capable of combining with four molecules of oxygen, leading to rapid and reversible oxygen loading. When fully loaded with oxygen, it is called oxyhemoglobin, while hemoglobin that has released oxygen is called reduced hemoglobin or deoxyhemoglobin. As hemoglobin binds oxygen,...
5.3K
Rh Blood Group01:19

Rh Blood Group

2.5K
The Rhesus (Rh) antigen is crucial in determining blood groups and ensuring compatibility during blood transfusions.
2.5K
Disorders of Erythrocytes01:27

Disorders of Erythrocytes

1.9K
Disorders of erythrocytes, or red blood cells (RBCs), include a range of conditions affecting their number, shape, or function.
Erythrocyte disorders can be broadly categorized into two main types: anemic and polycythemic conditions.
A low oxygen-carrying capacity of the blood due to the loss, lower production, or destruction of erythrocytes is termed anemia. Hemorrhagic anemia, for example, occurs when bleeding from an external wound or internal ulcer reduces erythrocyte counts.
On the other...
1.9K
Overview of Hematopoiesis01:20

Overview of Hematopoiesis

7.7K
Hematopoiesis, or blood cell production, is a vital biological process that begins early in embryonic development and continues throughout life. This process generates the various types of cells found in blood, including red blood cells, white blood cells, and platelets from hematopoietic stem cells (HSCs).
Developmental Phases of Hematopoiesis
Initially, HSCs are formed in the embryonic yolk sac, a critical site for early blood cell production. These stem cells subsequently migrate to other...
7.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A New Fetal Hemoglobin-Related Phenotype in Sickle Cell Anemia.

American journal of hematology·2026
Same author

Exa-cel in Children with Transfusion-Dependent β-Thalassemia or Sickle Cell Disease.

The New England journal of medicine·2026
Same author

Modeling Genetic Diversity in Sickle Cell Disease Reveals Heterogeneous Responses to HbF-Inducing Therapies.

bioRxiv : the preprint server for biology·2026
Same author

PGC-1α agonism via oral administration of ZLN005 induces fetal hemoglobin and is antisickling in sickle mice.

Blood advances·2026
Same author

One cell at a time: HbF distribution in sickle cell disease.

Blood advances·2026
Same author

One cell at a time: HbF distribution in sickle cell disease.

Blood advances·2026

Related Experiment Video

Updated: Dec 11, 2025

A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy
07:24

A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy

1.8K

Fetal hemoglobin in sickle cell anemia.

Martin H Steinberg1

  • 1Division of Hematology/Oncology, Department of Medicine, Center of Excellence for Sickle Cell Disease, Center for Regenerative Medicine, Genome Science Institute, Boston University School of Medicine and Boston Medical Center, Boston, MA.

Blood
|August 19, 2020
PubMed
Summary

Fetal hemoglobin (HbF) can significantly improve sickle cell disease outcomes. Research explores HbF

Area of Science:

  • Genetics and Molecular Biology
  • Hematology
  • Pharmacology

Background:

  • Fetal hemoglobin (HbF) plays a crucial role in mitigating sickle cell disease (SCD) pathophysiology and clinical severity.
  • Understanding HbF's genetic regulation and its impact on SCD subphenotypes is key to developing effective therapies.

Purpose of the Study:

  • To review quantitative trait loci for HbF and β-globin haplotypes, particularly in Middle Eastern populations.
  • To examine the differential impact of HbF on SCD pathophysiology and subphenotypes.
  • To discuss clinical implications of HbF distribution variability and therapeutic strategies for HbF gene reactivation.

Main Methods:

  • Literature review focusing on genetic loci, haplotype analysis, and HbF's role in SCD.
  • Analysis of studies investigating HbF's impact on disease subphenotypes and erythrocyte distribution.

More Related Videos

Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry
08:23

Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry

Published on: November 5, 2019

10.2K
Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
05:23

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload

Published on: March 14, 2017

20.1K

Related Experiment Videos

Last Updated: Dec 11, 2025

A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy
07:24

A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy

1.8K
Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry
08:23

Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry

Published on: November 5, 2019

10.2K
Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
05:23

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload

Published on: March 14, 2017

20.1K
  • Examination of pharmacologic and cell-based approaches for reactivating HbF gene expression.

    • Main Results:

    • Identified HbF quantitative trait loci and β-globin haplotypes, with emphasis on Middle Eastern variants.
    • Detailed the varied effects of HbF on SCD pathophysiology and clinical subphenotypes.
    • Highlighted clinical relevance of HbF levels and distribution in erythrocytes.
    • Summarized progress in pharmacologic and cell-based therapies for HbF reactivation.

    Conclusions:

    • Advances in understanding HbF gene expression and genomic editing offer promising avenues for SCD therapeutics.
    • Cell-based therapeutic approaches targeting HbF reactivation hold potential for curative intent in sickle cell disease.