Related Experiment Video
Updated: Dec 11, 2025
Evaluation of Biomaterials for Bladder Augmentation using Cystometric Analyses in Various Rodent Models
Published on: August 9, 2012
Cardiovascular risk independently predicts small functional bladder storage capacity
Thomas F Monaghan1, Connelly D Miller2, Christina W Agudelo2
1Department of Urology, SUNY Downstate Health Sciences University, 450 Clarkson Avenue, Box 79, Brooklyn, NY, 11203, USA. monaghantf@gmail.com.
Insights
Men with higher atherosclerotic cardiovascular disease (ASCVD) risk scores are more likely to have a small functional bladder capacity (FBC). This suggests a link between cardiovascular health and bladder function in men experiencing nocturia.
Area of Science:
- Urology
- Cardiology
- Geriatrics
Background:
- Cardiovascular disease is a leading cause of mortality and morbidity globally.
- Nocturia, or the need to urinate at night, affects a significant portion of the male population.
- Atherosclerotic cardiovascular disease (ASCVD) risk score quantifies 10-year risk of cardiovascular events.
Purpose of the Study:
- To investigate the association between the ASCVD risk score and functional bladder capacity (FBC) in men presenting with nocturia.
- To determine if higher ASCVD risk correlates with reduced FBC in an outpatient urology setting.
Main Methods:
- Secondary analysis of voiding diaries from men aged 40-79 with nocturia.
- Exclusion of patients with prior cardiovascular disease or nocturnal polyuria.
- Stratification based on high-risk ASCVD threshold (≥20%) and assessment for small FBC (≤200 ml), with logistic regression for association analysis.
Main Results:
- Eighty-four men were included; 42.9% met the high-risk ASCVD threshold.
- High-risk ASCVD patients were significantly more likely to have small FBC (63.9% vs. 29.2%, p=0.002).
- ASCVD risk score independently predicted small FBC on multivariate analysis, even after controlling for BMI and benign prostatic obstruction.
Conclusions:
- A small functional bladder capacity is associated with a higher predicted cardiovascular event rate in men with nocturia.
- This finding highlights a potential link between urological health and cardiovascular risk in aging men.
Purpose:
We aimed to determine the potential relationship between atherosclerotic cardiovascular disease (ASCVD) score, which equates to 10-year risk of atherosclerotic cardiovascular events, and functional bladder capacity (FBC) among men in the outpatient urology setting.
Methods:
We secondarily analyzed voiding diaries from men aged 40 to 79 years with nocturia. Patients with a history of cardiovascular disease or who had nocturnal polyuria were excluded. Patients were stratified by whether they met the high-risk ASCVD threshold (≥ 20%) following current cardiology consensus guidelines and assessed for the presence of small FBC (24-h maximum voided volume ≤ 200 ml). Logistic regression analyses were employed to explore associations between small FBC and ASCVD.
Results:
Eighty-four men (median ASCVD score 18.4 [IQR 12.8-26.9] %, age 66 [61-71] years, body mass index [BMI] 29.4 [26.4-32.7] kg/m2) were included, of whom 36 (42.9%) were high-risk and 48 (57.1%) fell below the high-risk threshold. High-risk patients were more likely to have small FBC (23 [63.9%] vs. 14 [29.2%], p = 0.002). ASCVD risk predicted small FBC on univariate analysis (p = 0.002). No such effect was observed with age (p = 0.116), BMI (p = 0.523), or benign prostatic obstruction (p = 0.180). The association between ASCVD risk and small FBC persisted on multivariate analysis after controlling for BMI and benign prostatic obstruction (p = 0.002). No significant predictors of small FBC were observed when age, a major determinant of ASCVD risk and independent correlate of small FBC, was substituted for ASCVD score (p = 0.108).
Conclusions:
Small FBC is related to a higher predicted cardiovascular event rate in men with nocturia.
Related Concept Videos
01:19Urodynamic Studies: Uroflowmetry
01:23Urinary Bladder
In males, the bladder is situated in front of the rectum, while in females, it is positioned anterior to the vagina and uterus. The bladder floor contains an inverted triangular area called the trigone, defined by the two ureteric...
01:22Imaging Studies VI: Voiding Cystourethrography and Cystography
01:27Regulation of Stroke Volume
Preload refers to the degree of stretch on the heart before it contracts. It's analogous to the stretching of a rubber band; the more it's stretched, the more forcefully it snaps back. This concept is encapsulated in the Frank-Starling law of the...
01:19Anatomy of the Genitourinary System II: Bladder and Urethra
01:21Nursing Assessment of the Genitourinary System I: Health History