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Sex Differences in Immunometabolism: An Unexplored Area
Suresh Mishra1,2, Geetika Bassi3, Yang Xin Zi Xu3
1Faculty of Health Sciences, Department of Internal Medicine, College of Medicine, University of Manitoba, Winnipeg, Canada. suresh.mishra@umanitoba.ca.
Methods in Molecular Biology (Clifton, N.J.)
|August 19, 2020
Summary
Sex differences are crucial in immunometabolism, impacting immune cell function and metabolic homeostasis. Ignoring these differences limits therapeutic potential for metabolic and immune diseases, hindering precision medicine development.
Area of Science:
- Immunometabolism
- Cellular Metabolism
- Immune Cell Function
Background:
- Immunometabolism research has grown significantly over three decades.
- Cellular metabolism critically regulates immune cell plasticity and systemic metabolic homeostasis.
- Current research often overlooks sex differences, despite their integral role in health and disease.
Purpose of the Study:
- To highlight the understudied area of sex differences in immunometabolism.
- To emphasize the importance of sex differences in immune and metabolic health.
- To encourage research into sex-based precision medicine.
Main Methods:
- This chapter discusses potential drivers of sex differences in immunometabolism.
- It touches upon unanswered questions requiring scientific attention.
- Literature review and conceptual discussion.
Main Results:
- Sex differences are pervasive in adipose, metabolic, and immune functions.
- Understanding these differences can unlock new research avenues.
- Ignoring sex differences limits therapeutic applications and health maintenance.
Conclusions:
- Sex differences are a fundamental aspect of immunometabolism.
- Addressing sex differences is essential for advancing precision medicine.
- Further research is needed to fully understand and leverage sex-based variations in immunometabolism for therapeutic benefit.
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