Related Experiment Video

Updated: Dec 11, 2025

Large-Animal Model of Donation after Circulatory Death and Normothermic Regional Perfusion for Cardiac Assessment
07:49

Large-Animal Model of Donation after Circulatory Death and Normothermic Regional Perfusion for Cardiac Assessment

Published on: May 10, 2022

1.9K

Heat shock protein 60 and cardiovascular diseases: An intricate love-hate story

Indumathi Krishnan-Sivadoss1, Iván A Mijares-Rojas1, Ramiro A Villarreal-Leal1

  • 1Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Medicina Cardiovascular y Metabolómica, Monterrey, Nuevo León, México.

Medicinal Research Reviews
|August 19, 2020
PubMed

Insights

Heat shock protein 60 (HSP60) plays a dual role in cardiovascular diseases (CVDs), offering protection yet potentially driving inflammation. Targeting HSP60 shows promise as a therapeutic strategy for CVDs.

Area of Science:

  • Cardiovascular biology
  • Immunology
  • Molecular medicine

Background:

  • Cardiovascular diseases (CVDs) stem from complex pathophysiological processes affecting the heart and blood vessels.
  • Inflammation, triggered by cellular stress (apoptosis, oxidative stress), is a primary driver of cardiovascular dysfunction.
  • Heat shock protein 60 (HSP60) acts as an intracellular chaperone with a dual role in cardiovascular homeostasis.

Purpose of the Study:

  • To review the multifaceted functions of HSP60 in cellular and immune regulation.
  • To explore the implications of HSP60 in the development and progression of CVDs.
  • To summarize therapeutic strategies targeting HSP60 for cardiovascular and other diseases.

Main Methods:

  • Literature review of studies on HSP60.
  • Analysis of HSP60's role in cellular stress responses.
  • Examination of HSP60's involvement in innate and adaptive immunity.

Main Results:

  • HSP60 can protect against cellular injury but also initiate damaging immune responses.
  • HSP60 is implicated in the pathogenesis and advancement of cardiovascular diseases.
  • Studies indicate HSP60 targeting as a potential therapeutic avenue.

Conclusions:

  • HSP60's complex role necessitates careful consideration for therapeutic interventions.
  • Targeting HSP60 may offer novel treatment options for cardiovascular conditions.
  • Further research is warranted to fully elucidate HSP60's therapeutic potential.

Keywords:
heart diseasesheart failureheat shock proteinsimmunitytherapeutic

More Related Videos

A Murine Closed-chest Model of Myocardial Ischemia and Reperfusion13:42

A Murine Closed-chest Model of Myocardial Ischemia and Reperfusion

Published on: July 17, 2012

29.5K
Studies of Chaperone-Cochaperone Interactions using Homogenous Bead-Based Assay06:51

Studies of Chaperone-Cochaperone Interactions using Homogenous Bead-Based Assay

Published on: July 21, 2021

3.1K

Related Concept Videos

Psychoneuroimmunology: Cardiovascular Disease01:27

Psychoneuroimmunology: Cardiovascular Disease

Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
245
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
407
Blood Pressure Imbalances and Circulatory Shock01:24

Blood Pressure Imbalances and Circulatory Shock

Disorders affecting blood volume, vascular tone, or vascular function can disrupt vascular homeostasis, including conditions like hypertension, hemorrhage, and shock.
Blood Pressure: Hypertension and Hypotension
Normal blood pressure is 120/80 mm Hg. Elevated blood pressure is 120-129/under 80 mm Hg. Hypertension, warranting treatment at 130/80 mm Hg, is often asymptomatic and can lead to severe cardiovascular events, aneurysms, peripheral arterial disease, chronic renal disease, or cardiac...
1.3K
Hypertension II: Pathophysiology01:29

Hypertension II: Pathophysiology

Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
566
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
242
Pathophysiology of Heart Failure01:17

Pathophysiology of Heart Failure

Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
2.5K