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Updated: Dec 11, 2025

Protocols for Testing the Toxicity of Novel Insecticidal Chemistries to Mosquitoes

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Published on: February 13, 2019

New Mosquitocide Derived From Volcanic Rock.

Jean M Deguenon¹, Claudia Riegel², Erin R Cloherty-Duvernay²

¹Department of Entomology and Plant Pathology, North Carolina State University, Raleigh, NC.

Journal of Medical Entomology

|August 19, 2020

Summary

This summary is machine-generated.

A novel mechanical insecticide derived from volcanic rock (MIVR) shows high residual activity against disease-carrying mosquitoes. This insecticide offers a new mode of action, crucial for combating growing insecticide resistance in mosquito control programs.

Keywords:

Imergard™WP mechanical insecticide mosquito-borne disease mosquitoes residual spray

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Published on: January 16, 2015

Area of Science:

Medical Entomology
Materials Science
Environmental Science

Background:

Vector-borne diseases like malaria and dengue pose significant global health risks.
Increasing insecticide resistance in mosquitoes necessitates novel control methods.
Current chemical insecticides face challenges due to resistance and environmental concerns.

Purpose of the Study:

To identify and evaluate novel insecticides for mosquito control.
To assess the efficacy and mode of action of a mineral-derived mechanical insecticide.
To explore alternatives to conventional chemical insecticides for disease prevention.

Main Methods:

Laboratory screening of industrial minerals for insecticidal activity against Anopheles gambiae.
Modified WHO cone tests to determine mortality rates and time to 50% mortality.
Field studies evaluating residual activity against Aedes aegypti, Aedes albopictus, and Culex quinquefasciatus.
Scanning electron microscopy to investigate insecticide-mosquito interactions.

Main Results:

A novel mechanical insecticide derived from volcanic rock (MIVR) was discovered.
MIVR demonstrated rapid mortality (5h to 50% mortality) under high humidity.
Field studies showed >80% residual activity for 9 weeks against multiple mosquito species.
MIVR particles were primarily transferred to mosquito legs, indicating a mechanical mode of action.

Conclusions:

MIVR is a promising mechanical insecticide with a novel mode of action, distinct from current chemical insecticides.
Its high residual efficacy and lack of repellency make it suitable for indoor and outdoor residual spraying.
MIVR represents a potential new tool for integrated mosquito management and disease vector control, with commercial development underway as Imergard™WP.