Modular and Stereoselective Synthesis of C-Aryl Glycosides via Catellani Reaction
Weiwei Lv1, Yanhui Chen1, Si Wen1
1College of Materials Science & Engineering, Huaqiao University, Xiamen 361021, China.
Abstract:
In this work, we describe a Catellani-type C-H glycosylation to provide rapid access to various highly decorated α-C-(hetero)aryl glycosides in a modular and stereoselective manner (>90 examples). The termination step is flexible, which is demonstrated by ipso-Heck reaction, hydrogenation, Suzuki coupling, and Sonogashira coupling. Application of this methodology has been showcased by preparing glycoside-pharmacophore conjugates and a dapagliflozin analogue. Notably, the technology developed herein represents an unprecedented example of Catellani-type alkylation involving an SN1 pathway.
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