Curcumin Promotes Primary Oral Wound Healing in a Rat Model

Curcumin is known as an anti-tumor, anti-aging, and wound healing promoter. The aim this study was to examine the effect of 2% curcumin paste application on primary wound healing in a palatal rat model. A mid-crestal incision was initiated on the maxillary alveolar ridge. A full thickness flap was raised on either side of the incision and was then repositioned and sutured. Experimental groups consisted of 2% curcumin (Cur), orabase (O), cut only (C), and intact control-no incision, no paste (N). Curcumin 2% and orabase were applied postoperatively every 12 h for 3 consecutive days. Rats were equally killed after 1 and 2 weeks. Histological data included-epithelial gap, inflammatory infiltrate, myofibroblasts, epithelial and connective tissue stem cell-related markers. Data were collected at two time points-1 and 2 weeks. There was no residual epithelial gap 1 week from incision in the Cur and O group vs. residual gap in the C group (P = .031). Curcumin 2% was associated with upregulated expression of epithelial-related markers (P < .05) although not statistically significant compared with orabase alone. Upregulation of connective tissue-related markers (P < .05) was unique to curcumin 2%. Curcumin promotes epithelial gap closure in a primary wound healing model in rats, possibly through upregulation of connective tissue stem cells leading to further epithelial differentiation and proliferation. Tel-Aviv University Animal Care Committee (approval Number: 01-16-031).