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Topical and systemic antifungal agents.

G P Bodey1

  • 1Department of Medical Specialities, University of Texas System Cancer Center, M.D. Anderson Hospital and Tumor Institute, Houston.

The Medical Clinics of North America
|May 1, 1988
PubMed
Summary
This summary is machine-generated.

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Superficial fungal infections are common, with many topical treatments available. Systemic fungal infections are rising, particularly in immunocompromised individuals, and Amphotericin B, while effective, has significant toxicities.

Area of Science:

  • Mycology
  • Infectious Diseases
  • Pharmacology

Background:

  • Superficial fungal infections are prevalent and contribute to significant patient morbidity.
  • Topical antifungal agents effectively manage most superficial mycoses.
  • Systemic fungal infections are increasingly observed, especially in immunocompromised populations.

Purpose of the Study:

  • To review the current landscape of fungal infections and their treatment options.
  • To highlight the challenges in managing systemic fungal infections.
  • To discuss the role and limitations of Amphotericin B.

Main Methods:

  • Literature review of epidemiological trends in fungal infections.
  • Analysis of treatment modalities for superficial and systemic mycoses.

Related Experiment Videos

  • Evaluation of the efficacy and toxicity profiles of antifungal agents.

    • Main Results:

    • Topical therapies are generally effective for superficial fungal infections.
    • Systemic fungal infections pose a growing therapeutic challenge.
    • Amphotericin B is a critical agent for systemic mycoses but carries substantial toxicity risks.

    Conclusions:

    • While superficial fungal infections have established treatments, systemic infections require careful management.
    • The toxicity of Amphotericin B necessitates ongoing research into safer and equally effective alternatives.
    • Advances in understanding fungal pathogenesis are crucial for developing novel antifungal strategies.