Related Experiment Video
Updated: Aug 7, 2026

Identification of Growth Inhibition Phenotypes Induced by Expression of Bacterial Type III Effectors in Yeast
Published on: March 30, 2010
Yeast STE7, STE11, and STE12 genes are required for expression of cell-type-specific genes
S Fields1, D T Chaleff, G F Sprague
1Department of Microbiology, State University of New York, Stony Brook 11794.
Abstract:
Cell type specialization in yeast haploids involves the mutually exclusive expression of one of two sets of genes, the a-specific and alpha-specific genes. We demonstrated that the products of the STE7, STE11, and STE12 genes were required for the expression of both gene sets. RNA levels transcribed from these gene sets were significantly decreased but not abolished in haploids containing a null mutation in the STE7, STE11, or STE12 gene. Transcript levels from the a- and alpha-specific gene sets were not further reduced in strains harboring mutations in all three STE genes, suggesting that STE7, STE11, and STE12 are required for the same aspect of transcription. We further showed that the requirement for these products was not the same for each member of a particular gene set. However, for any given a- or alpha-specific gene, the effect on RNA levels of any of the three ste mutations was similar.
Related Concept Videos
Yeast Signaling
Cell Specific Gene Expression
Cell Specific Gene Expression
Maintenance of the ES Cell State
Gene Regulation During Sporulation
Bioreactor Controls-III

