Correlations between cardiac troponin I and nonsustained ventricular tachycardia in hypertrophic obstructive

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Limin Liu1, Shangyu Liu1, Lishui Shen1

  • 1Clinical EP Lab & Arrhythmia Center, Fuwai Hospital, National Center for Cardiovascular Diseases, State Key Laboratory of Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Clinical Cardiology
|August 19, 2020
PubMed

Insights

Elevated cardiac troponin I (cTnI) is linked to nonsustained ventricular tachycardia (NSVT) in hypertrophic obstructive cardiomyopathy (HOCM). This biomarker may help assess arrhythmia risk and sudden cardiac death (SCD) risk in HOCM patients.

Area of Science:

  • Cardiology
  • Biomarker Research
  • Clinical Diagnostics

Background:

  • Nonsustained ventricular tachycardia (NSVT) is a significant risk factor for sudden cardiac death (SCD) in patients with hypertrophic obstructive cardiomyopathy (HOCM).
  • Limited data exists on the correlation between cardiac biomarkers and NSVT in HOCM patients.

Purpose of the Study:

  • To investigate the association between NSVT occurrence and circulating biomarkers in a large Chinese HOCM cohort.
  • To examine biomarkers related to myocardial injury (cardiac troponin I, cTnI), cardiac function (NT-pro BNP), and inflammation (hs-CRP).

Main Methods:

  • Recruited 755 consecutive HOCM patients undergoing systematic cardiac evaluations and biomarker assessments.
  • Patients were categorized into NSVT (n=138) and non-VT (n=617) groups based on 24-hour Holter monitoring.
  • Circulating biomarkers including cTnI, NT-pro BNP, and hs-CRP were analyzed.

Main Results:

  • Significantly elevated levels of cTnI and NT-pro BNP were observed in patients with NSVT compared to the non-VT group.
  • Multivariable analysis confirmed cTnI as an independent predictor of NSVT (OR=1.675, P<.001).
  • cTnI levels correlated with the severity of ventricular arrhythmias and SCD risk in HOCM patients; a threshold of cTnI ≥ 0.0265 ng/mL predicted NSVT (AUC=0.707, P<.001).

Conclusions:

  • Elevated cTnI is an independent determinant of NSVT in HOCM patients.
  • cTnI serves as a valuable biomarker for assessing ventricular arrhythmia status and SCD risk in HOCM.
Abstract

Keywords:
cardiac troponin Ihypertrophic obstructive cardiomyopathynonsustained ventricular tachycardiasudden cardiac death

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