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Estimating paediatric hepatitis C prevalence in the United States

Harman Rahal1, Sandra Boutros2, Mohamad Farhat2

  • 1Department of Internal Medicine, UCLA Medical Center, Los Angeles, CA, USA.

Journal of Viral Hepatitis
|August 19, 2020
PubMed

Insights

Hepatitis C virus (HCV) infection in children is rising, with a significant increase in vertical transmission from mothers. Public health efforts must prioritize pediatric HCV to address this growing concern.

Area of Science:

  • Hepatology
  • Pediatric Infectious Diseases
  • Epidemiology

Background:

  • Hepatitis C virus (HCV) infection affects over 70 million globally.
  • Prevalence data predominantly focus on adults, with limited information on pediatric populations.
  • Vertical transmission is a primary route of HCV infection in children.

Purpose of the Study:

  • To examine hepatitis C virus (HCV) prevalence in children.
  • To estimate pediatric HCV rates by analyzing maternal infection prevalence.
  • To highlight the increasing risk of HCV in infants born to infected mothers.

Main Methods:

  • Analysis of maternal HCV infection rates between 2001 and 2017.
  • Estimation of HCV prevalence among live births based on maternal data.
  • Examination of trends in pediatric HCV infections.

Main Results:

  • Maternal HCV infection affected approximately 0.24% of births between 2001-2017, a 261% increase.
  • An estimated 0.01% of live births were infected with HCV, showing a 245% rise.
  • Women of childbearing age represent an increasing proportion of HCV cases in the US.

Conclusions:

  • HCV epidemiology is shifting, with a growing number of women of childbearing age being infected.
  • Infants born to HCV-infected mothers are at significant risk.
  • Increased public health focus on pediatric HCV is recommended.

Keywords:
HCVHepatitis Cestimationpaediatricprevalence

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