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Related Experiment Video

Updated: Dec 11, 2025

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From BDNF to reading: Neural activation and phonological processing as multiple mediators.

Sara Mascheretti1, Meaghan V Perdue2, Bei Feng3

  • 1Child Psychopathology Unit, Scientific Institute, IRCCS E. Medea, Bosisio Parini, LC, Italy.

Behavioural Brain Research
|August 19, 2020
PubMed
Summary

The BDNF Val66Met gene variant influences reading skills indirectly. It affects brain activation and phonological processing, which in turn impact reading ability in children.

Keywords:
BDNF-Val(66)Met polymorphismCompensatory mechanismsIntermediate phenotypesReadingSerial multiple mediation model

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Area of Science:

  • Neuroscience
  • Genetics
  • Developmental Psychology

Background:

  • The BDNF gene plays a crucial role in neuronal development and plasticity.
  • The Val66Met polymorphism in the BDNF gene is linked to brain structure, function, and susceptibility to neurodevelopmental disorders.
  • Recent studies associate this polymorphism with reading abilities and neural activity in reading circuits.

Purpose of the Study:

  • To investigate whether intermediate phenotypes, specifically brain activation and phonological skills, mediate the relationship between the BDNF Val66Met polymorphism and reading or reading disability.
  • To elucidate the pathway from genetic variation to complex cognitive behaviors like reading.

Main Methods:

  • A serial multiple mediation model was employed.
  • The study included a sample of 94 children aged 5–13 years.
  • Analysis focused on the association between BDNF genotype, brain activation, phonological processing, and reading performance.

Main Results:

  • No direct association was found between the BDNF genotype and reading performance.
  • The genotype was significantly associated with brain activation in regions relevant to reading and general cognitive functions.
  • This brain activation, in turn, was linked to phonological processing abilities, which were subsequently associated with reading outcomes.

Conclusions:

  • The BDNF Val66Met polymorphism influences reading ability through a pathway involving altered brain activation and phonological processing.
  • Brain imaging data and neurocognitive traits serve as effective intermediate phenotypes for understanding complex behaviors.
  • These findings highlight the interplay between genetics, brain function, and cognitive skills in reading development.