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Clostridioides difficile infections in Alberta: The validity of administrative data using ICD-10 diagnostic codes for

Ted Pfister¹, Elissa Rennert-May², Jennifer Ellison¹

¹Infection Prevention and Control, Alberta Health Services, AB, Canada.

American Journal of Infection Control

|August 19, 2020

Abstract

Background:

Clostridioides difficile infection (CDI) is one of the most common health care-associated infections. This study assessed the validity of the Discharge Abstract Database (DAD) compared to a traditional clinical surveillance method for identifying CDI.

Methods:

Retrospective analysis of all DAD records with International Statistical Classification of Diseases and Related Health Problems 10th Revision (ie, ICD-10) diagnostic code A04.7 (enterocolitis due to CDI) between April 2015 and March 2019 were compared to a clinical dataset of positive inpatient CDI for all acute care facilities in Alberta, Canada. Sensitivity and positive predictive values were calculated using R version 3.6.0.

Results:

The DAD had a sensitivity of 85.0% (95% confidence interval: 84.1%-85.8%) and a positive predictive value of 80.0% (95% confidence interval: 79.2%-80.0%). The CDI rate per 1,000 admissions over the study period was 28% higher in the DAD compared to Infection Prevention and Control surveillance.

Discussion:

The DAD does not distinguish symptomatic cases from asymptomatic cases and so indicators to identify symptomatic disease would need to be applied, potentially through a linkage to antibiotic treatment orders available in patient management systems.

Conclusions:

The DAD is moderately sensitive for identifying symptomatic CDI cases in Alberta, Canada and caution should be applied when interpreting rates based on administrative data.

Keywords:

Administrative databases Clostridioides difficile Electronic surveillance Hospitalized patients Validation

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