Related Experiment Video
Updated: Dec 11, 2025

Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles
Published on: January 26, 2024
ESR1 polymorphisms and risk of preeclampsia
1Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Sichuan University West China Second University Hospital, Chengdu, China.
Objective:
Polymorphism of estrogen receptor α (ESR1) polymorphisms plays an important role in the adaptation of increased uterine blood flow during gestation. Published data on the association between the ESR1 polymorphisms and preeclampsia risk are controversial. A meta-analysis was performed to assess whether the polymorphisms of ESR1 are associated with preeclampsia risk.
Methods:
Medline, Embase, China National Knowledge Infrastructure, and Chinese Biomedicine Databases were searched to identify eligible studies. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) for ESR1 polymorphisms and preeclampsia were appropriately derived from fixed-effects or random-effects models.
Results:
A total of seven studies were enrolled in this meta-analysis. The pooled analyses revealed that both ESR1 PvuII and XbaI polymorphisms were not associated with preeclampsia risk. No significant heterogeneity among the including studies was found in all models of ESR1 PvuII and XbaI polymorphisms.
Conclusions:
Present meta-analysis demonstrates that ESR1 polymorphisms may not be correlated to preeclampsia risk.
More Related Videos
11:35Screening for Functional Non-coding Genetic Variants Using Electrophoretic Mobility Shift Assay EMSA and DNA-affinity Precipitation Assay DAPA
Published on: August 21, 2016
07:26High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment
Published on: July 18, 2017
Related Concept Videos
Non-LTR Retrotransposons
Treatment for Pulmonary Arterial Hypertension: Endothelin Receptor Antagonists
ETs are synthesized through a complex sequence of enzymatic steps, primarily involving an enzyme referred to as endothelin-converting enzyme...
Single Nucleotide Polymorphisms-SNPs
Comparing Copy Number Variations and SNPs
Copy number variations or CNVs are the structural variations that cover more than 1kb of DNA sequence. The single nucleotide polymorphism (SNP), on the other hand, is a single nucleotide change or a point mutation that is found in more than 1%...
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies