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Related Experiment Video

Updated: Dec 11, 2025

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Cell-Based Therapy for Stroke: Musing With Muse Cells.

You Jeong Park1, Kuniyasu Niizuma2, Maxim Mokin1

  • 1Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, Tampa, Florida (Y.J.P., M.M., C.V.B.).

Stroke
|August 20, 2020
PubMed
Summary
This summary is machine-generated.

Multipotent progenitor cells called Muse cells show promise for stroke recovery. These stem cells can integrate into brain tissue and improve function after ischemic stroke in preclinical models.

Keywords:
braincentral nervous systemregenerative medicinestem cellstransplantation

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Area of Science:

  • Neuroscience
  • Regenerative Medicine
  • Stem Cell Biology

Background:

  • Stem cell therapy holds potential for central nervous system repair after ischemic stroke.
  • Mesenchymal stem cells show limited engraftment in vivo despite clinical benefits.
  • Regenerating ischemic brain tissue in humans using stem cells remains a challenge.

Purpose of the Study:

  • To highlight Multilineage-differentiating stress-enduring (Muse) cells as a potential stem cell source for ischemic stroke therapy.
  • To review the biological properties of Muse cells relevant to stroke regeneration.
  • To emphasize the potential of Muse cells in advancing regenerative medicine for stroke.

Main Methods:

  • Review of preclinical studies on Muse cells in various disease models, including stroke.
  • Focus on studies demonstrating Muse cell mobilization, differentiation, and engraftment.
  • Analysis of results from mouse lacunar stroke models involving intravenous Muse cell transplantation.

Main Results:

  • Muse cells, a subset of mesenchymal stem cells, possess unique reparative capabilities.
  • Preclinical studies show Muse cells can mobilize, differentiate, and engraft into damaged host tissue.
  • Intravenous Muse cell transplantation in mice led to functional recovery and neural engraftment post-stroke.

Conclusions:

  • Muse cells demonstrate significant therapeutic potential for ischemic stroke due to their regenerative properties.
  • Their ability to engraft and integrate into neural networks makes them a promising candidate for stroke cell therapy.
  • Further elucidation of Muse cell mechanisms will optimize stem cell therapy for stroke and regenerative medicine.