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White Matter Abnormalities in Spontaneous Subarachnoid Hemorrhage: A Tract-Based Spatial Statistics Study
Sung Jun Lee1, Min Son Kim1, Sung Ho Jang1
1Department of Physical Medicine and Rehabilitation, College of Medicine, Yeungnam University, Namku, Daegu, Republic of Korea.
Stroke
|August 20, 2020
Summary
Spontaneous subarachnoid hemorrhage patients show widespread white matter abnormalities. Tract-based spatial statistics revealed significant differences in fractional anisotropy across numerous brain regions compared to controls.
Area of Science:
- Neuroimaging
- Neurology
- White Matter Integrity
Background:
- Spontaneous subarachnoid hemorrhage (sSAH) following aneurysmal rupture can lead to significant neurological deficits.
- Understanding the underlying white matter changes is crucial for patient outcomes.
Purpose of the Study:
- To investigate white matter abnormalities in patients with sSAH.
- To utilize tract-based spatial statistics (TBSS) for detailed analysis.
Main Methods:
- Recruited 16 patients with sSAH and 18 healthy controls.
- Performed voxel-wise statistical analysis of fractional anisotropy (FA) data using TBSS.
- Calculated mean FA values across the tract skeleton and within 48 regions of interest.
Main Results:
- Significant FA differences (P<0.05) were found in 44 out of 48 regions of interest between patients and controls.
- No significant differences were observed in the retrolenticular parts of the internal capsule, right superior longitudinal fasciculus, and right superior corona radiata.
Conclusions:
- TBSS analysis detected widespread white matter abnormalities in patients with sSAH.
- These findings highlight the extensive impact of sSAH on white matter structure.
