Related Experiment Video
Updated: Dec 11, 2025

Broth Microdilution In Vitro Screening: An Easy and Fast Method to Detect New Antifungal Compounds
Published on: February 14, 2018
Theoretical and Spectroscopic Characterization of API-Related Azoles in Solution and in Solid State
Marta Marín-Luna1, Rosa M Claramunt2, José Elguero3
1Departamento de Química Orgánica, Facultad de Química, Universidad de Murcia, Regional Campus of International Excellence "Campus Mare Nostrum", 30100 Murcia, Spain.
Abstract:
Azoles are a family of five-membered azacyclic compounds with relevant biological and pharmacological activity. Different subclasses of azoles are defined depending on the atomic arrangement and the number of nitrogen atoms present in the ring: pyrazoles, indazoles, imidazoles, benzimidazoles, triazoles, benzotriazoles, tetrazoles and pentazoles. The complete characterization of their structure and the knowledge about their crystal packing and physical and chemical properties are of vital importance for the advancement in the design of new azole-containing drugs. In this review, we report the latest recent contributions to azole chemistry, in particular, those in which theoretical studies have been performed.
More Related Videos
Related Concept Videos
Aryldiazonium Salts to Azo Dyes: Diazo Coupling
Fungal Group Zygomycota
Pharmaceutical Alternatives: Polymorphic Form-Related and Particle Size-Related Therapeutic Nonequivalence

