Thiosemicarbazides: Updates on Antivirals Strategy
Alok Kumar Moharana1, Rudra Narayan Dash1, Bharat Bhusan Subudhi1
1Drug Development and Analysis Laboratory, School of Pharmaceutical Sciences, Siksha 'O' Anusandhan (Deemed to be University), Bhubaneswar-751029, Odisha, India.
Mini Reviews in Medicinal Chemistry
|August 20, 2020
Summary
Thiosemicarbazides show promise as antiviral scaffolds against emerging viral threats like chikungunya and dengue viruses. Research over three decades highlights their potential, with modifications enhancing safety and efficacy for new antiviral therapies.
Area of Science:
- Medicinal Chemistry
- Virology
- Drug Discovery
Background:
- Increasing viral resistance and limited antiviral drug discovery necessitate novel therapeutic approaches.
- Neglected tropical viruses such as chikungunya, dengue, and Japanese encephalitis viruses are emerging as global health concerns.
- Antiviral research has historically explored thiosemicarbazide derivatives, inspiring ongoing development.
Purpose of the Study:
- To systematically review the research on thiosemicarbazide scaffolds for antiviral applications.
- To analyze structure-activity relationships and translational potential of thiosemicarbazide-derived compounds.
- To explore strategies for enhancing the safety and efficacy of thiosemicarbazide-based antivirals.
Main Methods:
- Comprehensive literature review of antiviral research involving thiosemicarbazides from 1990-2020.
- Analysis of chemical modification strategies including hybridization, cyclization, and substitution.
- Examination of thiosemicarbazides as metal complexes or chelators against viral infections.
Main Results:
- Significant efforts have been made to develop potent antiviral agents using the thiosemicarbazide scaffold.
- Hybridization, cyclization, and substitution have proven effective in enhancing antiviral activity and safety.
- Thiosemicarbazides' ability to form coordinate bonds offers unique mechanisms for antiviral action.
Conclusions:
- Thiosemicarbazide derivatives represent a valuable and versatile scaffold for developing new antiviral therapies.
- Further research into structure-activity relationships and translational suitability is crucial for clinical progression.
- This scaffold holds potential for addressing infections caused by challenging and emerging viruses.
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