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[Bone loss during aging or how one becomes osteoporotic?].

D Kuntz1

  • 1Clinique Rhumatologique, Centre Viggo Petersen, Hôpital Lariboisière, Paris.

Revue Du Rhumatisme Et Des Maladies Osteo-Articulaires
|January 1, 1988
PubMed
Summary

Ageing causes significant bone loss, particularly in cancellous bone like vertebrae. Women experience greater bone density reduction post-menopause due to accelerated cancellous bone loss.

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Area of Science:

  • Gerontology
  • Bone Biology
  • Skeletal Aging

Context:

  • Bone remodeling dynamics differ between cancellous and cortical bone.
  • Age-related bone loss affects both bone types but at different rates.
  • Vertebral bodies are predominantly composed of cancellous bone, making them susceptible to significant age-related loss.

Purpose:

  • To elucidate the differential impact of aging on cancellous and cortical bone.
  • To quantify age-related bone loss in men and women.
  • To investigate accelerated bone loss in women post-menopause and post-ovariectomy.

Summary:

  • Aging leads to bone loss in both cancellous and cortical bone, with cancellous bone experiencing more pronounced effects due to its higher remodeling rate.
  • Quantitatively, aging results in approximately 50% cancellous and 35% cortical bone loss in women, and 35% cancellous and 20% cortical bone loss in men.
  • Post-menopausal women exhibit accelerated bone loss, with vertebral trabecular bone loss potentially reaching 1-2% annually, and up to 12% in the two years following ovariectomy.

Impact:

  • Provides a clearer understanding of age-related skeletal changes and sex-based differences.
  • Highlights the vulnerability of vertebral bone to age-related and hormonal changes.
  • Informs potential therapeutic strategies targeting age-related bone density reduction.

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