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Related Concept Videos

mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

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The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
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Related Experiment Video

Updated: Dec 11, 2025

Establishment and Characterization of Three Afatinib-resistant Lung Adenocarcinoma PC-9 Cell Lines Developed with Increasing Doses of Afatinib
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Correction to: Afatinib is active in osteosarcoma cell lines.

Marlid Cruz-Ramos1,2, Yessica Zamudio-Cuevas3, Daniel Medina-Luna3,4

  • 1Oncology Translational Laboratory, Hospital Universitario Fundación Jiménez Díaz, Madrid, Spain. marlid.cruz@gmail.com.

Journal of Cancer Research and Clinical Oncology
|August 20, 2020
PubMed
Summary

Afatinib demonstrates significant activity in osteosarcoma cell lines, indicating its potential as a therapeutic agent for this bone cancer. Further research is warranted to explore its clinical efficacy.

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Area of Science:

  • Oncology
  • Molecular Biology
  • Pharmacology

Context:

  • Osteosarcoma is a primary bone cancer with limited treatment options.
  • Targeted therapies are being investigated to improve patient outcomes.
  • The role of specific tyrosine kinase inhibitors in osteosarcoma is an area of active research.

Purpose:

  • To evaluate the in vitro activity of afatinib against osteosarcoma cell lines.
  • To determine the molecular mechanisms underlying afatinib's potential anti-cancer effects in osteosarcoma.

Summary:

  • Afatinib, a tyrosine kinase inhibitor, was tested on various human osteosarcoma cell lines.
  • The study found that afatinib inhibited cell proliferation and induced apoptosis in these cell lines.
  • These findings suggest that afatinib possesses anti-osteosarcoma activity.

Impact:

  • This research identifies afatinib as a potential targeted therapy for osteosarcoma.
  • The results may guide future preclinical and clinical studies investigating afatinib in osteosarcoma treatment.
  • Understanding afatinib's activity provides insights into targeting specific signaling pathways in bone cancer.