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Compositional Features and Codon Usage Pattern of Genes Associated with Anxiety in Human.

¹Department of Zoology, Moinul Hoque Choudhury Memorial Science College, Algapur, Hailakandi, Assam, 788150, India. arif.uddin29@gmail.com.

Molecular Neurobiology

|August 20, 2020

Summary

Codon usage bias (CUB) in anxiety genes shows low bias, with frequent codons ending in G or C. Both mutation pressure and natural selection likely influence CUB patterns in these genes.

Keywords:

Anxiety mutation pressure Codon usage bias Gene expression level Natural selection

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Area of Science:

Genomics
Molecular Biology
Bioinformatics

Background:

Codon usage bias (CUB) describes the non-uniform use of synonymous codons.
CUB analysis is crucial for understanding genome organization, gene expression, and evolution.
No prior studies investigated CUB in genes associated with anxiety.

Purpose of the Study:

To analyze codon usage patterns in genes related to anxiety using a bioinformatics approach.
To identify over-represented and under-represented codons in anxiety-associated genes.
To investigate the influence of mutation pressure and natural selection on CUB in these genes.

Main Methods:

Bioinformatic analysis of protein-coding sequences from anxiety-related genes.
Calculation of the improved effective number of codons (Nc).
Analysis of relative synonymous codon usage (RSCU) and nucleotide composition (GC and AT content).
Correlation analysis between nucleotide composition and codon positions.

Main Results:

Low overall codon usage bias was observed, with mean Nc values ranging from 43.55 to 55.06 (mean 44.57).
GC content was 54.76% and AT content was 45.24%.
Frequently used codons predominantly ended with C or G.
Over-represented codons included CTG, ATC, GTG, AGC, ACC, and GCC; under-represented codons included TTA, CTT, CTA, ATA, GTT, GTA, TCG, CCG, GCG, CAA, and CGT.
Significant correlations were found between nucleotide composition and the third codon position, and between GC12 and GC3, suggesting the impact of mutation pressure and natural selection.

Conclusions:

Genes associated with anxiety exhibit low codon usage bias.
Mutation pressure and natural selection are significant factors shaping codon usage patterns in anxiety-related genes.
Directional mutation pressure may affect all codon positions.