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Environment Controls Biomolecule Release from Dynamic Covalent Hydrogels.

Bruno Marco-Dufort1, Jack Willi1, Felipe Vielba-Gomez1

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Dynamic covalent hydrogels offer injectable drug delivery. Surface erosion, not network changes, controls biomolecule release, guiding future biomaterial design for enhanced drug delivery applications.

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Drug Delivery Systems

Background:

  • Dynamic covalent hydrogels are promising for controlled release due to their injectable nature.
  • Fundamental understanding of how network design and environment affect biomolecule release is lacking.

Purpose of the Study:

  • To investigate the release of biomolecules from boronic-ester-based dynamic covalent hydrogels.
  • To understand the influence of network properties and environmental factors on release kinetics.

Main Methods:

  • Fabrication of boronic-ester-based dynamic covalent hydrogels.
  • In vitro release studies using β-galactosidase as a model biologic.
  • Systematic investigation of temperature and competitive binders on release.

Main Results:

  • Surface erosion and mass loss were identified as the primary mechanisms governing biomolecule release.
  • A statistical model was developed to describe release rates based on binding equilibria.
  • Release was influenced by external factors like temperature and competitive binders.

Conclusions:

  • Surface erosion is the key mechanism for controlled release in these hydrogels.
  • The developed model accurately describes release kinetics.
  • Findings provide guidance for designing dynamic covalent hydrogels for drug delivery.