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Author Spotlight: Advancements in Hypoxia-Sensitive CAR-T Therapy for Enhanced Cancer Immunotherapy
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Preventing Ubiquitination Improves CAR T Cell Therapy via 'CAR Merry-Go-Around'
Nicole M Chapman1, Stephen Gottschalk2, Hongbo Chi1
1Department of Immunology, St Jude Children's Research Hospital, Memphis, TN 38105, USA.
Immunity
|August 20, 2020
Abstract:
Chimeric antigen receptor (CAR) T cells are potent drivers of antitumor immunity, but promoting durable CAR T cell responses remains challenging. In this issue of Immunity, Li et al. (2020) show that blockade of CAR ubiquitination induces CAR recycling to the cell surface, leading to increased CAR T cell cytotoxicity and longevity by amplifying 41BB-dependent signaling and mitochondrial metabolism.
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