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Gitelman syndrome in pregnancy: a case series
Jingfei Zhang1, Feiran Liu1, Jinghui Tu1
1Department of Obstetrics and Gynecology, Beijing Shijitan Hospital, Capital Medical University, Beijing, China.
Summary
Pregnancy outcomes for women with Gitelman syndrome (GS) are generally favorable. Early electrolyte monitoring aids efficient diagnosis and management, allowing for successful vaginal delivery in well-controlled cases.
Area of Science:
- Obstetrics and Gynecology
- Genetics
- Internal Medicine
Background:
- Gitelman syndrome (GS) is a rare genetic disorder affecting renal salt reabsorption.
- Pregnancy in women with GS presents unique challenges due to electrolyte imbalances.
Purpose of the Study:
- To evaluate maternal and fetal outcomes in pregnant women diagnosed with Gitelman syndrome.
- To identify optimal management strategies for Gitelman syndrome during pregnancy.
Main Methods:
- Retrospective analysis of clinical data from five pregnant patients with Gitelman syndrome.
- Data collected from Beijing Shijitan Hospital between 2013 and 2019.
Main Results:
- Five women with GS gave birth to eight newborns; all infants had good perinatal outcomes.
- Maternal complications were minimal; three patients delivered vaginally, two via cesarean section.
- Early diagnosis (first or second trimester) and electrolyte supplementation were key management strategies.
Conclusions:
- Maternal and perinatal outcomes for Gitelman syndrome pregnancies are typically favorable.
- Early electrolyte screening in the first trimester is crucial for timely diagnosis and management.
- Well-managed Gitelman syndrome patients can achieve successful vaginal deliveries.
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