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Updated: Dec 11, 2025

Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development
Published on: October 30, 2013
[Unusual evolution of reactive arthritis after endovesical immunotherapy with BCG]
A Hernández Fernández1, C Pinilla-Gracia, L Rodríguez Nogué
1Servicio de Cirugía Ortopédica y Traumatología. Hospital Universitario Miguel Servet. Zaragoza. alberto.hdez.fdez@gmail.com.
Abstract:
Intravesical instillation of BCG (Bacille Calmette-Guerin) is a therapy prepared with weakened strains of Mycobacterium bovis and is an effective complementary treatment for high-risk (non-musculoinfiltrating or non-invasive) bladder cancer. Although its safety for clinical use is high, endovesical immunotherapy is not without complications. Arthralgia and arthritis are infrequent, but potentially severe, complications, the early diagnosis of which can allow adequate medical treatment and avoid chronification of the pathology. This case shows the therapeutic management of hip osteoarthritis in a 59-year-old woman, a rare and serious complication, secondary to a rare pathology such as reactive arthritis due to BCG instillation.
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