Reference Intervals for Bone Histomorphometric Measurements Based on Data from Healthy Premenopausal Women

Area of Science:

• Bone biology and histology
• Human physiology
• Osteoporosis research

Background:

• Establishing normal reference intervals for bone histomorphometry in premenopausal women is critical for accurate clinical assessment.
• Limited data exists for bone histomorphometric measurements in healthy premenopausal populations.

Purpose of the Study:

• To establish normal reference intervals for static and dynamic bone histomorphometric measurements in healthy premenopausal women.
• To provide a benchmark for evaluating bone health and disease in women.

Main Methods:

• Trans-iliac bone biopsies were performed on 62 healthy premenopausal women (19 Black, 43 White, ages 20-53).
• Static and dynamic histomorphometric variables were analyzed in cancellous and cortical bone.
• Data was pooled across ethnic groups due to no significant differences in age, BMI, or bone remodeling.

Main Results:

• Normal reference intervals for static and dynamic bone histomorphometric variables in cancellous and cortical bone were established.
• No significant correlations were found between bone remodeling variables and age or BMI.
• No significant differences in bone remodeling were observed between Black and White women.

Conclusions:

• This study successfully established comprehensive reference intervals for bone histomorphometry in healthy premenopausal women.
• These reference intervals are valuable tools for the clinical evaluation of bone health and the diagnosis of bone metabolic disorders in women.
• The findings contribute to a better understanding of normal bone remodeling processes in women across different ethnicities.