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Related Experiment Video

Updated: Dec 11, 2025

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Dissociable fronto-striatal functional networks predict choice impulsivity.

Qiang Wang1,2,3, Chenyu Lv4, Qinghua He5,6

  • 1Key Research Base of Humanities and Social Sciences of the Ministry of Education, Academy of Psychology and Behavior, Tianjin Normal University, Tianjin, 300387, China. wangqiang113@gmail.com.

Brain Structure & Function
|August 21, 2020
PubMed
Summary
This summary is machine-generated.

Distinct fronto-striatal functional connectivity predicts choice impulsivity. Specifically, nucleus accumbens and caudate connectivity with prefrontal areas are key to understanding inter-temporal choices.

Keywords:
Choice impulsivityFunctional connectivityInter-temporal choiceMultivariate pattern analysisPrefrontal cortexStriatum

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Area of Science:

  • Neuroscience
  • Cognitive Neuroscience
  • Neuroimaging

Background:

  • Fronto-striatal structural connectivity is linked to choice impulsivity.
  • The role of distinct fronto-striatal functional coupling in impulsive choices remains largely unexplored.

Purpose of the Study:

  • To investigate how different fronto-striatal functional connectivities predict choice impulsivity.
  • To examine the predictive power of functional coupling between striatal subregions and prefrontal cortex on delay discounting.

Main Methods:

  • Utilized seed-based resting-state functional MRI (rsfMRI) and multivariate pattern analysis (MVPA) in a sample of 429 participants.
  • Employed an adaptive delay-discounting task to quantify choice impulsivity.
  • Divided the striatum into three subregions: nucleus accumbens (NAcc), caudate, and putamen.

Main Results:

  • Functional coupling between the NAcc and limbic/dorsolateral prefrontal cortex predicted delay-discounting rate.
  • Functional coupling between the caudate and dorsal prefrontal cortex, including the dorsomedial prefrontal cortex (DMPFC), also predicted delay-discounting rate.
  • No significant predictive pattern was found for putamen-prefrontal functional connectivity.

Conclusions:

  • Fronto-striatal functional connectivity plays a crucial role in the neural mechanisms underlying choice impulsivity.
  • Specific striatal subregions (NAcc and caudate) and their functional connections with distinct prefrontal areas differentially contribute to inter-temporal decision-making.