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Atherogenic Index of Plasma Is an Independent Risk Factor for Coronary Artery Disease and a Higher SYNTAX Score

Luzhao Wang1, Fangyao Chen2, Chai Xiaoqi1

  • 1Department of Cardiology, Hanzhong Central Hospital, Hanzhong, China.

Angiology
|August 21, 2020
PubMed

Insights

The atherogenic index of plasma (AIP) can help predict coronary artery disease (CAD) and high SYNTAX scores (SS). A best diagnostic cutoff value of 2.035 for CAD and 2.23 for high SS was identified in the Chinese population.

Area of Science:

  • Cardiovascular Medicine
  • Biomarkers
  • Diagnostic Accuracy

Background:

  • Coronary artery disease (CAD) poses a significant global health challenge.
  • Identifying reliable biomarkers for CAD risk stratification is crucial for early intervention.
  • The atherogenic index of plasma (AIP) has emerged as a potential indicator of cardiovascular risk.

Purpose of the Study:

  • To determine the optimal diagnostic cutoff value of AIP for predicting CAD.
  • To investigate the correlation between AIP and the SYNTAX score (SS) in patients with CAD.
  • To evaluate AIP's utility as a biomarker for CAD risk in the Chinese population.

Main Methods:

  • Retrospective study including 2253 CAD patients and 1347 non-CAD controls.
  • Coronary angiography and SYNTAX score calculation using network software.
  • Multivariate logistic regression and Receiver Operating Characteristic (ROC) curve analysis to determine diagnostic cutoffs and assess predictive performance.

Main Results:

  • AIP was significantly different between CAD and non-CAD groups (P < .01).
  • AIP is an independent risk factor for CAD (aOR=2.248) and high SS (aOR=1.623).
  • Optimal AIP cutoff values: 2.035 for CAD prediction (AUC=0.733) and 2.23 for SS ≥ 23 (AUC=0.653).

Conclusions:

  • AIP serves as a valuable independent risk factor for CAD and high SS.
  • Established AIP cutoff values can aid in the early diagnosis and risk stratification of CAD.
  • AIP shows potential as a cost-effective biomarker for CAD prevention in the Chinese population.

Keywords:
SYNTAX scoreatherogenic index of plasmacoronary artery disease

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