Related Experiment Video
Updated: Dec 11, 2025

Prospective, Randomized, and Controlled Study of a Human Umbilical Cord Mesenchymal Stem Cell Injection for Treating Diabetic Foot Ulcers
Published on: March 3, 2023
Hirudotherapy in Wound Healing.
Harikrishna K R Nair1, Nazni Wasi Ahmad2, Han Lim Lee2
1Hospital Kuala Lumpur, Kuala Lumpur, Malaysia.
Medicinal leech therapy effectively reduces pain and promotes wound healing by increasing blood flow. This ancient treatment, using sterile leeches, showed promising results in a small study for pain management and tissue repair.
Area of Science:
- Biomedical Science
- Integrative Medicine
- Parasitology
Background:
- Leech therapy is an ancient medical practice with a history spanning 3000 years.
- Medicinal leeches, particularly *Hirudo medicinalis*, have been employed for various therapeutic applications.
- Leeches aid in bloodletting, reduce tissue swelling, and enhance healing by restoring circulation.
Purpose of the Study:
- To evaluate the efficacy and duration of wound healing using sterile medicinal leeches (*Hirudinaria manillensis*).
- To assess the effectiveness of leech therapy in managing pain and promoting wound repair.
Main Methods:
- Sterile medicinal leeches (*Hirudinaria manillensis*) were used for treatment.
- Leeches were applied using sterile forceps and gloves, remaining in place until satiated.
- Used leeches were safely disposed of following biohazard protocols, including sterilization with 70% alcohol and incineration.
Main Results:
- All three patients experienced significant improvements in their conditions.
- Notable reductions in pain and enhanced sense of balance were observed.
- All treated wounds demonstrated successful healing, indicating improved perfusion.
Conclusions:
- Leech therapy is effective in alleviating pain and accelerating wound healing through increased blood perfusion.
- The study suggests potential benefits for pain management and wound repair.
- Further research with larger sample sizes is recommended to establish statistical significance.
Related Concept Videos
Phases of Wound Repair
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...
Overview of Regeneration and Repair
Regeneration
All animals have varying degrees of...
Varicose Veins II: Diagnostic Studies and Interprofessional Care
Inflammatory Response II: Inflammatory Exudate and Tissue Repair
The typical wound exudate is odorless, transparent, straw-colored, thin, and watery. Exudate, however, can differ depending on the state of wound healing. Likewise, the...
Venous Thrombosis III: Interprofessional Care

