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Lower CH50 as a predictor for intractable or recurrent lupus enteritis: A retrospective observational study
Yusuke Yoshida1, Takuji Omoto1,2, Hiroki Kohno1
1Department of Clinical Immunology and Rheumatology, Hiroshima University Hospital, Hiroshima, Japan.
Modern Rheumatology
|August 21, 2020
Summary
Lower serum CH50 levels indicate a poor treatment response in patients with lupus enteritis (LE), a gastrointestinal complication of systemic lupus erythematosus (SLE). This finding helps predict outcomes for LE patients.
Area of Science:
- Gastroenterology
- Rheumatology
- Immunology
Background:
- Lupus enteritis (LE) is a rare but serious gastrointestinal manifestation of systemic lupus erythematosus (SLE).
- Identifying prognostic factors for LE is crucial for effective patient management.
Purpose of the Study:
- To identify prognostic factors associated with poor treatment response in patients diagnosed with lupus enteritis.
Main Methods:
- Retrospective analysis of clinical characteristics of 13 patients (17 episodes) with LE between 2009 and 2019.
- Comparison of clinical data between patients with good and poor treatment responses.
Main Results:
- Serum CH50 levels were significantly lower in the poor response group (p=0.0095).
- Higher anti-cardiolipin β2-glycoprotein I antibody titers and moderate-dose glucocorticoid initiation were more frequent in the poor response group.
- Multivariable analysis identified low serum CH50 as an independent predictor of poor response to induction therapy.
Conclusions:
- Lower serum CH50 levels at initial treatment predict inadequate response in lupus enteritis patients.
- Serum CH50 may serve as a valuable biomarker for predicting LE treatment outcomes.
