Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Hallucinogens and Psychedelics01:27

Hallucinogens and Psychedelics

458
Hallucinogens are psychoactive substances that profoundly alter perceptual experiences, generating unreal visual and sensory images. Often referred to as psychedelic drugs — a term derived from the Greek words "psyche" (mind) and "delos" (revealing) — these substances include marijuana and lysergic acid diethylamide (LSD), among others. These drugs vary in intensity and effects.
Marijuana, derived from the dried leaves and flowers of the hemp plant, contains...
458
CNS Stimulants: Psychedelic Agents01:22

CNS Stimulants: Psychedelic Agents

519
Hallucinogens, also known as psychedelic drugs, are a class of substances known for their ability to alter perception, cognition, and emotions. Despite their profound effects on the mind, these drugs are non-addictive, setting them apart from many other abused substances. The mechanism of action of these drugs lies in their impact on the 5-HT2A receptor in the brain. Upon activation, this receptor couples to Gq-type G proteins, triggering a cascade that releases intracellular calcium. This...
519
Altered States of Awareness01:06

Altered States of Awareness

839
Altered states of consciousness represent significant deviations from one's normal mental state. These deviations can range from subtle changes in awareness to profound transformations in perception, thought processes, and sensory experiences. Altered states of consciousness can be triggered by various factors, including drug use, meditation, hypnosis, illness, or even intense fatigue.
The ingestion of substances like stimulants or hallucinogens leads to chemical alterations in the brain...
839
An Overview of Psychoactive Drugs01:28

An Overview of Psychoactive Drugs

454
Psychoactive drugs impact brain function, influencing perception, mood, consciousness, cognition, and behavior. These substances are grouped based on their effects and the mechanisms by which they act.
Stimulants such as cocaine, amphetamines, and nicotine enhance brain activity, leading to increased alertness, attention, and energy. These drugs typically raise heart rate, blood pressure, and body temperature. While they can induce feelings of euphoria, their misuse can result in severe health...
454
Lucid Dreaming01:10

Lucid Dreaming

387
Lucid dreaming is a unique state of consciousness where an individual realizes they are dreaming while still in the dream. This awareness allows them to manipulate their dream environment consciously. Researchers like Stephen LaBerge have significantly contributed to the understanding of lucid dreams, highlighting that during these dreams, certain areas of the brain, such as the prefrontal cortex, that involve self-awareness and thought evaluation show increased activity.
Studies have shown...
387
Measurement of Bioavailability: Pharmacodynamic Methods01:20

Measurement of Bioavailability: Pharmacodynamic Methods

115
Pharmacodynamic methods provide insights into a drug's effects on physiological processes over time and play a crucial role in understanding bioavailability and therapeutic efficacy. These methods can be broadly classified into acute pharmacological and therapeutic response approaches, each with distinct mechanisms and applications.The acute pharmacological response method directly correlates a drug's physiological effects, such as ECG or pupil diameter changes, to its time course in the body.
115

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effects of repeated low-dose LSD on neuropsychological functioning in adults with ADHD: a randomized placebo-controlled study.

Psychopharmacology·2026
Same author

Use of psychedelic treatments in psychiatric clinical practice: an EPA policy paper.

European psychiatry : the journal of the Association of European Psychiatrists·2025
Same author

Self-rated costs and benefits of conventional and alternative adult ADHD treatments.

Scientific reports·2024
Same author

Psilocybin induces acute and persisting alterations in immune status in healthy volunteers: An experimental, placebo-controlled study.

Brain, behavior, and immunity·2023
Same author

Cannabis containing equivalent concentrations of delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) induces less state anxiety than THC-dominant cannabis.

Psychopharmacology·2022
Same author

Spontaneous and deliberate creative cognition during and after psilocybin exposure.

Translational psychiatry·2021

Related Experiment Video

Updated: Dec 11, 2025

A General Method for Evaluating Deep Brain Stimulation Effects on Intravenous Methamphetamine Self-Administration
09:16

A General Method for Evaluating Deep Brain Stimulation Effects on Intravenous Methamphetamine Self-Administration

Published on: January 22, 2016

15.6K

[Microdosing with psychedelics: what do we know?]

K P C Kuypers

    Tijdschrift Voor Psychiatrie
    |August 21, 2020
    PubMed
    Summary

    Microdosing psychedelics may offer symptom relief for psychiatric disorders, with users reporting improved mood and focus. Further placebo-controlled studies are needed to confirm efficacy and identify suitable patient populations.

    Area of Science:

    • Neuroscience
    • Psychiatry
    • Pharmacology

    Background:

    • Microdosing (MD) involves repeated use of small psychedelic doses (e.g., psilocybin, LSD).
    • Growing popularity and scientific interest in MD for potential therapeutic benefits.
    • Retrospective user reports suggest clinical potential for psychiatric conditions.

    Purpose of the Study:

    • To evaluate the theoretical potential of psychedelic microdosing for symptom relief in psychiatric disorders.
    • To review existing evidence on MD's effects on behavior, psychological functioning, and well-being.

    Main Methods:

    • Systematic literature search of PubMed and Medline databases (January 10, 2020).
    • Included 23 articles after de-duplication and relevance screening.
    • Analyzed data from uncontrolled online questionnaires and limited experimental studies.

    More Related Videos

    Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study
    07:30

    Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study

    Published on: August 18, 2020

    7.3K
    HSV-Mediated Transgene Expression of Chimeric Constructs to Study Behavioral Function of GPCR Heteromers in Mice
    07:30

    HSV-Mediated Transgene Expression of Chimeric Constructs to Study Behavioral Function of GPCR Heteromers in Mice

    Published on: July 9, 2016

    7.5K

    Related Experiment Videos

    Last Updated: Dec 11, 2025

    A General Method for Evaluating Deep Brain Stimulation Effects on Intravenous Methamphetamine Self-Administration
    09:16

    A General Method for Evaluating Deep Brain Stimulation Effects on Intravenous Methamphetamine Self-Administration

    Published on: January 22, 2016

    15.6K
    Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study
    07:30

    Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study

    Published on: August 18, 2020

    7.3K
    HSV-Mediated Transgene Expression of Chimeric Constructs to Study Behavioral Function of GPCR Heteromers in Mice
    07:30

    HSV-Mediated Transgene Expression of Chimeric Constructs to Study Behavioral Function of GPCR Heteromers in Mice

    Published on: July 9, 2016

    7.5K

    Main Results:

    • User reports indicate positive effects of MD on mood, concentration, focus, and productivity.
    • Reported negative effects include physical discomfort and increased fear.
    • Experimental studies in healthy individuals show subtle impacts on cognitive processes and brain connectivity.

    Conclusions:

    • Experimental findings and user reports warrant further investigation into low-dose psychedelic clinical potential.
    • Placebo-controlled trials are essential to determine efficacy for specific populations and processes.
    • Further research needed to clarify age, diagnosis, and cognitive/emotional targets for MD effectiveness.