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Updated: Dec 11, 2025

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
Conosiligins A-D, Ring-Rearranged Tremulane Sesquiterpenoids from Conocybe siliginea
Juan He1, Chao-Jun Pu1, Meng Wang1
1School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, People's Republic of China.
Abstract:
Conosiligins A-D (1-4), four ring-rearranged sesquiterpenoids, were isolated from cultures of the basidiomycete Conocybe siliginea. Their structures and absolute configurations were determined by detailed spectroscopic analyses and equivalent circulating density (ECD) calculations. Compounds 1 and 2 possess a 5/8-fused ring system, while 3 has a 5/6-fused backbone conjugated with a γ-lactone. Compound 4 is a 5,6-seco tremulane derivative with the loss of a skeletal carbon, featuring a tetracyclic system involving a pyranone moiety. Compounds 3 and 4 inhibited Con A-induced T cell proliferation with IC50 values of 12.3 and 6.6 μM, respectively.
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