Divergence of Tissue-Memory T Cells: Distribution and Function-Based Classification
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Updated: Dec 11, 2025

Isolation of Mouse Kidney-Resident CD8+ T cells for Flow Cytometry Analysis
Published on: June 27, 2020
1Department of Immunology, Kindai University Faculty of Medicine, Osaka-Sayama, Osaka 589-8511, Japan.
Abstract:
Tissue-resident memory T cells (Trm) comprise the majority of memory cells in nonlymphoid tissues and play a predominant role in immunity at barrier surfaces. A better understanding of Trm cell maintenance and function is essential for the development of vaccines that confer frontline protection. However, it is currently challenging to precisely distinguish Trm cells from other T cells, and this has led to confusion in the literature. Here we highlight gaps in our understanding of tissue memory and discuss recent advances in the classification of Trm cell subsets based on their distribution and functional characteristics.
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