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Updated: Dec 11, 2025

Fully Processed Recombinant KRAS4b: Isolating and Characterizing the Farnesylated and Methylated Protein
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Published on: January 16, 2020

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BI-3406, a Potent and Selective SOS1-KRAS Interaction Inhibitor, Is Effective in KRAS-Driven Cancers through Combined

Marco H Hofmann1, Michael Gmachl2, Juergen Ramharter2

  • 1Boehringer Ingelheim RCV GmbH & Co KG, Vienna, Austria. marco.hofmann@boehringer-ingelheim.com norbert.kraut@boehringer-ingelheim.com.

Cancer Discovery
|August 21, 2020
PubMed
Summary

A new drug, BI-3406, targets SOS1, a KRAS activator, to treat KRAS-driven cancers. Combining SOS1 and MEK inhibitors offers a novel approach for difficult-to-treat KRAS-mutant tumors.

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