Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Blindness from quinine toxicity.

P Bacon1, D J Spalton, S E Smith

  • 1Medical Eye Unit, St Thomas's Hospital, London.

The British Journal of Ophthalmology
|March 1, 1988
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Prospects for observing and localizing gravitational-wave transients with Advanced LIGO, Advanced Virgo and KAGRA.

Living reviews in relativity·2020
Same author

GW190521: A Binary Black Hole Merger with a Total Mass of 150  M_{⊙}.

Physical review letters·2020
Same author

Characterization of transient noise in Advanced LIGO relevant to gravitational wave signal GW150914.

Classical and quantum gravity·2020
Same author

GW150914: First results from the search for binary black hole coalescence with Advanced LIGO.

Physical review. D. (2016)·2020
Same author

Increasing the Astrophysical Reach of the Advanced Virgo Detector via the Application of Squeezed Vacuum States of Light.

Physical review letters·2019
Same author

Search for Subsolar Mass Ultracompact Binaries in Advanced LIGO's Second Observing Run.

Physical review letters·2019
Same journal

Identifying patients with poor visual outcomes after primary rhegmatogenous retinal detachment surgery using machine learning.

The British journal of ophthalmology·2026
Same journal

Incidence of bilateral disease and choroidal neovascularisation in punctate inner choroiditis.

The British journal of ophthalmology·2026
Same journal

Reference map of multimodal vision deficits in intermediate age-related macular degeneration: contrast sensitivity and low-contrast visual acuity.

The British journal of ophthalmology·2026
Same journal

Commentary on 'identifying patients with poor visual outcomes after primary rhegmatogenous retinal detachment surgery using machine learning'.

The British journal of ophthalmology·2026
Same journal

Automated deep learning-based retinoschisis and detachment volume measurement in pathological myopia with posterior scleral contraction.

The British journal of ophthalmology·2026
Same journal

Bacterial keratitis: a global review of current practices, challenges and innovations.

The British journal of ophthalmology·2026
See all related articles

Quinine overdose can cause temporary blindness due to retinal toxicity. A stellate ganglion block did not improve vision in this case, suggesting it doesn't alter the natural course of quinine-induced retinal damage.

Area of Science:

  • Ophthalmology
  • Toxicology
  • Neuroscience

Background:

  • Quinine is used to treat malaria and other conditions.
  • Overdose can lead to visual disturbances, including blindness.
  • The mechanism of quinine's ocular toxicity is debated, with theories including retinal toxicity and vasoconstriction.

Observation:

  • A 47-year-old man presented with acute blindness following quinine overdose.
  • Fundus photography documented progressive retinal changes.
  • Visual acuity recovered to normal, but with persistent visual field constriction.

Findings:

  • Pupillary and electrodiagnostic tests were recorded.
  • A unilateral stellate ganglion block was administered without apparent benefit to the affected eye.

Related Experiment Videos

  • Literature review suggests quinine's ocular effects stem from direct retinal toxicity, not vasoconstriction.

    • Implications:

    • Stellate ganglion block may not be an effective treatment for quinine-induced visual loss.
    • Understanding the mechanism of quinine toxicity is crucial for managing overdose cases.
    • Further research is needed to confirm the efficacy of potential therapeutic interventions.