Time trends in incidence, comorbidity, and mortality of ischemic stroke in Denmark (1996-2016)
Related Experiment Video
Updated: Aug 1, 2026

Rapid, Safe, and Simple Manual Bedside Nucleic Acid Extraction for the Detection of Virus in Whole Blood Samples
Published on: June 30, 2018
Adelina Yafasova1, Emil Loldrup Fosbøl2, Mia Nielsen Christiansen2
1From the Department of Cardiology (A.Y., E.L.F., M.N.C., N.E.V., L.K., J.H.B.), Rigshospitalet, Copenhagen University Hospital; Departments of Cardiology (C.A., G.H.G.) and Neurology (C.K.), Herlev and Gentofte University Hospital, Hellerup, Denmark; Department of Medicine (C.A.), Section of Cardiovascular Medicine, Boston Medical Center, Boston University School of Medicine, MA; Institute of Clinical Medicine (C.K.), University of Copenhagen; Danish Center for Clinical Health Services Research (S.P.J.), Department of Clinical Medicine, Aalborg University; The Danish Heart Foundation (G.H.G.), Copenhagen; National Institute of Public Health (G.H.G.), University of Southern Denmark, Odense; Department of Cardiology (C.T.-P.), Nordsjællands Hospital, Hillerød; and Department of Cardiology (C.T.-P.), Aalborg University Hospital, Denmark. adelinay@hotmail.com.
Objective:
To examine whether the incidence, comorbidity, and mortality of first-time ischemic stroke changed in Denmark between 1996 and 2016 overall and according to age and sex using a nationwide cohort design.
Methods:
In this cohort study, 224,617 individuals ≥18 years of age admitted with first-time ischemic stroke between 1996 and 2016 were identified through Danish nationwide registries. We calculated annual age-standardized incidence rates and absolute 30-day and 1-year mortality risks. Furthermore, we calculated annual incidence rate ratios using Poisson regression, odds ratios for 30-day mortality using logistic regression, and hazard ratios for 1-year mortality using Cox regression.
Results:
The overall age-standardized incidence rates of ischemic stroke per 1,000 person-years increased from 1996 (2.70 [95% confidence interval [CI] 2.65-2.76]) to 2002 (3.25 [95% CI 3.20-3.31]) and then gradually decreased to below the initial level until 2016 (1.99 [95% CI 1.95-2.02]). Men had higher incidence rates than women in all age groups except 18 to 34 and ≥85 years. Absolute mortality risk decreased between 1996 and 2016 (30-day mortality from 17.1% to 7.6% and 1-year mortality from 30.9% to 17.3%). Women between 55 and 64 and ≥85 years of age had higher mortality than men. Similar trends were observed for all analyses after multivariable adjustment. The prevalence of atrial fibrillation, hypertension, diabetes mellitus, and use of lipid-lowering medication increased during the study period.
Conclusions:
The age-standardized incidence of first-time hospitalization for ischemic stroke increased from 1996 to 2002 and then gradually decreased to below the initial level until 2016. Absolute 30-day and 1-year mortality risks decreased between 1996 and 2016. These findings correspond to increased stroke prevention awareness and introduction of new treatments during the study period.
Related Concept Videos
Prevalence and Incidence
Prevalence indicates the proportion of individuals in a population who have a specific disease or health condition at a...
Stroke: Introduction and Types
Ischemic Stroke l: Introduction
Ischemic Stroke ll: Pathophysiology
Hemorrhagic Stroke l: Introduction
Hemorrhagic Stroke ll: Pathophysiology

