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Impact of calculated plasma volume status on all-cause and cardiovascular mortality: 4-year nationwide

Yoichiro Otaki1, Tetsu Watanabe1, Tsuneo Konta1

  • 1Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, Yamagata, Japan.

Plos One
|August 21, 2020
PubMed

Insights

Plasma volume status (PVS) is a significant risk factor for mortality in the general population. This study found that both high and low PVS independently predict all-cause and cardiovascular deaths, suggesting PVS is a crucial health marker.

Area of Science:

  • Cardiology
  • Public Health
  • Biostatistics

Background:

  • Plasma volume status (PVS) is increasingly recognized for its role in cardiovascular disease, particularly heart failure management.
  • The association between abnormal PVS and mortality risk in the general population remains unclear.
  • PVS quantifies plasma volume expansion and contraction.

Purpose of the Study:

  • To investigate the association between plasma volume status (PVS) and all-cause and cardiovascular mortality.
  • To determine if PVS is an independent risk factor for mortality in a large general population cohort.

Main Methods:

  • Utilized a nationwide Japanese health check-up database of 230,882 adults aged 40-75 years (2008-2011).
  • Followed subjects for four years, recording all-cause, cardiovascular, and non-cardiovascular deaths.
  • Defined high and low PVS using specific thresholds (≥ 7 and < -13.3, respectively) and employed multivariate Cox regression analysis.

Main Results:

  • High PVS was identified as an independent risk factor for all-cause, cardiovascular, and non-cardiovascular mortality.
  • Low PVS was a risk factor for cardiovascular deaths but a negative risk factor for non-cardiovascular deaths.
  • Incorporating PVS into existing cardiovascular risk models significantly improved predictive accuracy.

Conclusions:

  • This study provides the first prospective evidence linking PVS to all-cause and cardiovascular mortality in the general population.
  • Abnormal plasma volume status (both high and low) represents an additional, significant risk factor for mortality.
  • PVS measurement may enhance risk stratification for cardiovascular events and overall mortality.
Abstract

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