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Related Experiment Video

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Retinal Vascular Reactivity as Assessed by Optical Coherence Tomography Angiography
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Subretinal Fibrosis Detection Using Polarization Sensitive Optical Coherence Tomography.

Maximilian G O Gräfe1, Jacoba A van de Kreeke2, Joy Willemse1

  • 1LaserLaB Amsterdam, Department of Physics and Astronomy, Vrije Universiteit, Amsterdam, The Netherlands.

Translational Vision Science & Technology
|August 21, 2020
PubMed
Summary

Polarization-sensitive optical coherence tomography (PS-OCT) can reliably detect subretinal fibrosis (SRFib), a cause of vision loss. This advanced imaging method aids in diagnosing challenging cases where conventional methods fall short.

Keywords:
AMDOCTbirefringencepolarization sensitivesubretinal fibrosis

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Area of Science:

  • Ophthalmology
  • Biomedical Imaging
  • Retinal Diseases

Background:

  • Subretinal fibrosis (SRFib) is a significant cause of irreversible vision loss associated with submacular neovascularization.
  • Current diagnostic methods for SRFib lack reliability, hindering timely and accurate patient management.

Purpose of the Study:

  • To evaluate the efficacy of polarization-sensitive optical coherence tomography (PS-OCT) in detecting and characterizing subretinal fibrosis (SRFib).
  • To assess the diagnostic performance of PS-OCT in cases with suspected or doubtful SRFib.

Main Methods:

  • Utilized PS-OCT to image retinal lesions in 25 patients with suspected or confirmed SRFib.
  • Analyzed PS-OCT images for birefringence, cumulative phase retardation, and optic axis uniformity to identify collagen fibers characteristic of SRFib.
  • Compared PS-OCT findings with conventional diagnostic assessments made by three retinal specialists.

Main Results:

  • PS-OCT successfully scanned 29 eyes, confirming SRFib in 12 out of 13 eyes diagnosed by specialists.
  • PS-OCT corroborated the absence of SRFib in all 9 eyes where specialists did not suspect it.
  • In cases with inconsistent specialist evaluations, PS-OCT confirmed SRFib in 4 out of 7 eyes and ruled it out in 2 others.
  • PS-OCT provided crucial differentiating information in 6 out of 7 eyes with subretinal neovascular lesions.

Conclusions:

  • PS-OCT demonstrated high concordance with specialist diagnoses, confirming SRFib in 21 out of 22 eyes.
  • PS-OCT effectively distinguishes SRFib from other subretinal tissues, offering valuable diagnostic insights.
  • PS-OCT serves as a reliable tool for identifying and quantifying SRFib, particularly in ambiguous clinical scenarios.