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Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System
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Utilizing drug repurposing against COVID-19 - Efficacy, limitations, and challenges
Vineela Parvathaneni1, Vivek Gupta1
1Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St. John's University, Queens, NY 11439, USA.
Life Sciences
|August 21, 2020
Summary
Drug repurposing offers a cost-effective strategy for developing new therapies against COVID-19 (Coronavirus disease). This review examines the efficacy of repurposed drugs for COVID-19 and other respiratory viral infections.
Area of Science:
- Virology
- Pharmacology
- Infectious Diseases
Background:
- The COVID-19 pandemic, caused by SARS-CoV-2, has a high mortality rate with no available vaccines or effective antiviral therapies.
- Drug repurposing presents a time- and cost-efficient alternative for developing novel treatments.
Purpose of the Study:
- To review the current literature on the efficacy of repurposed drugs against COVID-19 and other coronavirus respiratory infections.
- To provide a comprehensive outlook on drug repurposing as a therapeutic discovery tool for respiratory viruses.
Main Methods:
- Literature review of scientific articles on drug repurposing for COVID-19 and related respiratory viral infections.
- Discussion of COVID-19 epidemiology, drug repurposing approaches, and specific examples for respiratory viruses.
Main Results:
- Analysis of the efficacy of various repurposed drugs against SARS-CoV-2 and other coronaviruses.
- Identification of challenges associated with repurposed drug utilization, including dosage and localized delivery.
Conclusions:
- Drug repurposing is a promising strategy for combating COVID-19 and other respiratory viral threats.
- Addressing limitations in dosage and delivery is crucial for the successful clinical application of repurposed drugs.
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