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Diffuse low grade glioma and pregnancy: Practical considerations and clinical tips
Teresa Somma1, Cinzia Baiano1, Laura Santi2
1Division of Neurosurgery, Department of Neurosciences, Reproductive and Odontostomatological Sciences, Università degli Studi di Napoli Federico II, Naples, Italy.
Clinical Neurology and Neurosurgery
|August 21, 2020
Summary
Pregnancy does not appear to affect survival in women with diffuse low-grade glioma (DLGG). While pregnancy
Area of Science:
- Neuro-oncology
- Reproductive medicine
- Oncology
Background:
- The relationship between pregnancy and diffuse low-grade glioma (DLGG) remains under-explored.
- Understanding this interaction is crucial for managing patients with DLGG who are pregnant or planning pregnancy.
Purpose of the Study:
- To investigate the impact of pregnancy on diffuse low-grade glioma (DLGG).
- To explore potential links between pregnancy and tumor recurrence in DLGG patients.
Main Methods:
- Retrospective analysis of 12 patients with DLGG.
- Inclusion criteria: DLGG diagnosis postpartum or recurrence post-pregnancy after prior surgery.
- Evaluation of extent of surgical resection (EOR), 2016 WHO classification, and preoperative ΔT2T1 MRI index.
Main Results:
- Four cases of newly diagnosed DLGG were identified postpartum.
- Seven previously operated patients experienced recurrence after pregnancy.
- One untreated patient showed significant tumor growth post-pregnancy.
Conclusions:
- Pregnancy does not seem to impact DLGG patient survival.
- The association between pregnancy and tumor recurrence is uncertain and may be coincidental.
- Further multicenter molecular studies are needed to elucidate pregnancy's influence on DLGG regrowth.
