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Published on: May 22, 2020
Altering model cell membranes by means of localized magnetic heating
Silvia Ruiz-Rincón1, Alejandro González-Orive2, Valeria Grazú3
1Instituto de Nanociencia de Aragón (INA), Campus Rio Ebro, Universidad de Zaragoza, C/Mariano Esquillor, s/n, 50018 Zaragoza, Spain; Laboratorio de Microscopias Avanzadas (LMA),Campus Río Ebro, Universidad de Zaragoza, C/Mariano Esquillor, s/n, 50018 Zaragoza, Spain; Instituto de Ciencia de Materiales de Aragón (ICMA), Universidad de Zaragoza-CSIC, C/Pedro Cerbuna 12, 50009 Zaragoza, Spain.
Abstract:
Isolated iron oxide magnetic nanoparticles (MNPs), 12 nm in diameter, coated with oleic acid molecules as capping agents have been deposited by the Langmuir-Blodgett (LB) method onto a model cell membrane incorporating 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) and Cholesterol (Chol) in the 1:1 ratio, which was also fabricated by the LB technique. Atomic Force Microscopy (AFM) experiments showed that the application of an alternating magnetic field results in the embedding of the MNPs through the phospholipidic layer. These experimental results reveal that the heating of individual MNPs may induce a local increase in the fluidity of the film with a large control of the spatial and temporal specificity.
