Related Experiment Video

Updated: Dec 11, 2025

Multidisciplinary Approach to Obesity Management: A Case Report
05:10

Multidisciplinary Approach to Obesity Management: A Case Report

Published on: May 30, 2025

757

Management of Type 2 Diabetes: Current Strategies, Unfocussed Aspects, Challenges, and Alternatives

Swapnil P Borse1,2, Abu Sufiyan Chhipa2,3, Vipin Sharma4

  • 1AYUSH-Center of Excellence, Center for Complementary and Integrative Health (CCIH), Interdisciplinary School of Health Sciences, Savitribai Phule Pune University (SPPU), Pune, India.

Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre
|August 21, 2020
PubMed

Insights

Type 2 diabetes mellitus (T2DM) management requires addressing overlooked factors and emphasizing lifestyle changes. This review explores T2DM development, current therapeutic flaws, and the potential of phytoconstituents as adjuncts.

Area of Science:

  • Endocrinology
  • Metabolic Diseases
  • Pharmacology

Background:

  • Type 2 diabetes mellitus (T2DM) is a prevalent adult endocrine disorder, primarily caused by insulin resistance and leading to chronic hyperglycemia.
  • The pathogenesis of T2DM involves complex interactions between genetic predispositions and environmental influences, impacting insulin action and beta-cell function.
  • Current anti-diabetic therapies often overlook key contributing factors and may have limitations.

Purpose of the Study:

  • To review critical, often unfocused, factors in T2DM development.
  • To highlight the importance of lifestyle modifications for effective T2DM management.
  • To evaluate current anti-diabetic strategies and explore novel therapeutic avenues.

Main Methods:

  • Literature review of T2DM pathogenesis, focusing on underemphasized etiological factors.
  • Analysis of current anti-diabetic treatment paradigms and their shortcomings.
  • Exploration of phytoconstituents as potential therapeutic adjuvants.

Main Results:

  • Identified key factors in T2DM development that are frequently neglected in clinical practice.
  • Emphasized the significant role of lifestyle interventions in managing T2DM.
  • Discussed limitations in existing anti-diabetic therapies and the potential of natural compounds.

Conclusions:

  • Effective T2DM management necessitates a comprehensive approach addressing both genetic and environmental factors, with a strong emphasis on lifestyle modifications.
  • Phytoconstituents show promise as multitargeting agents and adjuncts to conventional therapies, potentially mitigating side effects of synthetic drugs.
  • Re-evaluation of current anti-diabetic strategies is crucial for improving patient outcomes.
Keywords:
DiabetesGeneticsInsulin resistanceLifestyle modificationsPhytoconstituentsType-2 diabetes mellitusβ-cells

More Related Videos

A Zebrafish Model of Diabetes Mellitus and Metabolic Memory10:03

A Zebrafish Model of Diabetes Mellitus and Metabolic Memory

Published on: February 28, 2013

26.3K
Extracellular Glucose Depletion as an Indirect Measure of Glucose Uptake in Cells and Tissues Ex Vivo10:35

Extracellular Glucose Depletion as an Indirect Measure of Glucose Uptake in Cells and Tissues Ex Vivo

Published on: April 6, 2022

3.1K

Related Concept Videos

Diabetes: Management and Pharmacotherapy01:15

Diabetes: Management and Pharmacotherapy

The therapy for diabetes aims to alleviate hyperglycemia-related symptoms, prevent acute metabolic decompensation, and reduce chronic end-organ complications. Glycemic control is evaluated through short-term (self-monitoring, continuous glucose monitoring) and long-term (A1c, fructosamine) metrics, enabling near real-time tracking of blood glucose levels and reflecting glycemic control over specific time frames.
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
766
Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
4.1K
Diabetes Mellitus: Overview and Type I Subtype01:22

Diabetes Mellitus: Overview and Type I Subtype

Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
4.6K
Carbohydrate Metabolism01:36

Carbohydrate Metabolism

Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
13.3K
Diabetes: Symptoms, Diagnosis, and Complications01:15

Diabetes: Symptoms, Diagnosis, and Complications

For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
1.9K
Oral Hypoglycemic Agents: Biguanides and Glitazones01:26

Oral Hypoglycemic Agents: Biguanides and Glitazones

Biguanides, particularly metformin (Glucophage), are insulin sensitizers that enhance glucose uptake, thereby reducing insulin resistance. Unlike sulfonylureas, metformin doesn't prompt insulin secretion, which helps to curb hypoglycemia risk. Metformin is beneficial in treating conditions like polycystic ovary syndrome due to its insulin-resistance reduction capability. The drug's primary action involves curtailing hepatic gluconeogenesis, a significant contributor to high blood...
503