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Long-term sexual functioning in germ-cell tumor survivors
M Chovanec1,2,3, L Vasilkova4,5, L Petrikova6,7
12nd Department of Oncology, Faculty of Medicine, Comenius University, Klenova 1, Bratislava, 833 10, Slovak Republic. michal.chovanec1@gmail.com.
BMC Cancer
|August 22, 2020
Summary
Long-term germ-cell tumor (GCT) survivors may experience sexual dysfunction. Treatments like chemotherapy and radiotherapy can lead to disappointment and impact sexual function, with cisplatin doses affecting orgasm ability.
Area of Science:
- Oncology
- Sexual Medicine
- Survivorship Care
Background:
- Germ-cell tumors (GCT) survivors may face long-term adverse effects.
- Assessing long-term sexual functioning in GCT survivors is crucial for quality of life.
Purpose of the Study:
- To evaluate long-term sexual functioning in GCT survivors.
- To identify specific treatments impacting sexual health outcomes.
Main Methods:
- 170 GCT survivors completed a modified PROMIS Sexual Function and Satisfaction Questionnaire.
- Median follow-up was 9 years (range 5-32).
- Groups included active surveillance (AS) and treatment (Tx) cohorts (chemotherapy, radiotherapy, or both).
Main Results:
- Any treatment (Tx) correlated with erectile dysfunction compared to AS (P=0.04).
- Chemoradiotherapy (CTRT) was linked to reduced orgasm ability (P=0.04) and sexual disappointment (P=0.002).
- Higher cisplatin doses (≥400 mg/m²) independently predicted orgasmic dysfunction (P=0.03).
Conclusions:
- Sexual dysfunction is a significant long-term issue for GCT survivors.
- Chemotherapy plus radiotherapy impact sexual quality of life and desire.
- Cisplatin dose is a key factor in developing orgasmic dysfunction.
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