Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Alprazolam as an antidepressant.

M D Warner1, C A Peabody, H A Whiteford

  • 1Veterans Administration Medical Center, Palo Alto, Calif.

The Journal of Clinical Psychiatry
|April 1, 1988
PubMed
Summary

Alprazolam is an effective antidepressant for outpatients with major depressive disorder, showing comparable effectiveness to tricyclics with fewer side effects. Further research is needed for inpatient populations.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The cost of mental disorders: a systematic review.

Epidemiology and psychiatric sciences·2020
Same author

Perceived need and barriers to adolescent mental health care: agreement between adolescents and their parents.

Epidemiology and psychiatric sciences·2019
Same author

A profile of Australian mental health carers, their caring role and service needs: results from the 2012 Survey of Disability, Ageing and Carers.

Epidemiology and psychiatric sciences·2018
Same author

Intersectoral policy for severe and persistent mental illness: review of approaches in a sample of high-income countries.

Global mental health (Cambridge, England)·2017
Same author

Post-traumatic stress disorder and major depression in conflict-affected populations: an epidemiological model and predictor analysis.

Global mental health (Cambridge, England)·2017
Same author

A systematic review and meta-regression of the prevalence and incidence of perinatal depression.

Journal of affective disorders·2017

Area of Science:

  • Psychiatry
  • Pharmacology

Background:

  • Major depressive disorder (MDD) is a prevalent mental health condition.
  • Treatment options for MDD include antidepressants like tricyclics.
  • Alprazolam's potential antidepressant effects warrant investigation.

Purpose of the Study:

  • To evaluate the effectiveness of alprazolam as an antidepressant in treating major depressive disorder.
  • To compare alprazolam's efficacy and side effect profile with traditional tricyclic antidepressants.

Main Methods:

  • Systematic review of six controlled, double-blind studies.
  • Analysis focused on studies involving outpatients diagnosed with major depressive disorder.

Main Results:

  • Four studies with outpatients demonstrated alprazolam's clinical effectiveness.
  • Alprazolam showed comparable efficacy to tricyclics but with improved side effect profiles and better tolerance.
  • Two studies including inpatients did not yield conclusive results for this population.

Conclusions:

  • Alprazolam is an effective antidepressant for outpatient treatment of major depressive disorder.
  • Alprazolam offers a favorable side effect profile compared to tricyclics for outpatients.
  • Additional controlled studies are required to determine alprazolam's efficacy in inpatient settings.

Related Experiment Videos